4-1BBL Recombinant Rabbit Monoclonal Antibody [JE33-91] (HA721357)

UNIPROT #

P41273

PROTEIN NAME

4-1BBL

SYNONYMS

4 1BB L antibody;4 1BB ligand antibody;4 1BBL antibody;4-1BB ligand antibody;4-1BBL antibody;Cd137l antibody;Cd157l antibody;Homolog of mouse 4 1BB L antibody;Homolog of mouse 4 1BBL antibody;ILA ligand (TNF related) antibody;Ly63l antibody;Receptor 4 1BB ligand antibody;TNF superfamily member 9 antibody;TNFL9_HUMAN antibody;Tnfsf9 antibody;TNLG5A antibody;Tumor necrosis factor (ligand) superfamily member 9 antibody;Tumor necrosis factor ligand 5A antibody;Tumor necrosis factor ligand superfamily member 9 antibody;Tumor necrosis factor superfamily member 9 antibody

SUBCELLULAR LOCATION

Membrane.

FUNCTION

Tumor necrosis factor ligand superfamily member 9 also known as 4-1BB ligand or 4-1BBL or CD137L is a protein that in humans is encoded by the TNFSF9 gene. 4-1BBL is a type 2 transmembrane glycoprotein receptor that is found on APCs (antigen presenting cells) and binds to 4-1BB (also known as CD137). The 4-1BB/4-1BBL complex belongs to the TNFR:TNF superfamily, which is expressed on activated T Lymphocytes. The 4-1BB/4-1BBL complex consists of three monomeric 4-1BBs bound to a trimeric 4-1BBL. Each 4-1BB monomer binds to two 4-1BBLs via cysteine-rich domains (CRDs). The interaction between 4-1BB and the second 4-1BBL is required to stabilize their interactions. The link with 4-1BBL is largely made up of amino acids from the dynamic loops of the CRD2 and the β sheet of CRD3 of 4-1BB, according to a detailed study of the binding between the 4-1BB and 4-1BBL interface. CRD2 amino acids (T61, Q67, and K69) interact with the AA′ loop (Y110 and G114) and the intra-H-strand loop (Q227 and Q230) of 4-1BBL to form various hydrogen bond interactions.