ABI2 Recombinant Rabbit Monoclonal Antibody [JE53-89] (ET7110-42)

UNIPROT #

Q9NYB9

PROTEIN NAME

ABI2

SYNONYMS

Abelson interactor 2 antibody;ABI 2 antibody;Abi-2 antibody;ABI2 antibody;ABI2_HUMAN antibody;ABI2B antibody;Abl binding protein 3 antibody;Abl interacting protein 1 (SH3 containing protein) antibody;Abl interactor 2 antibody;Abl interactor protein 2b antibody;Abl-binding protein 3 antibody;AblBP3 antibody;AIP 1 antibody;Arg binding protein 1 antibody;Arg protein tyrosine kinase binding protein antibody;Arg-binding protein 1 antibody;ArgBP1 antibody;ARGBPIA antibody;ArgBPIB antibody;OTTHUMP00000163783 antibody;OTTHUMP00000163784 antibody;OTTHUMP00000206182 antibody;OTTHUMP00000206183 antibody;OTTHUMP00000206184 antibody;OTTHUMP00000206185 antibody;SSH3BP2 antibody

SEQUENCE SIMILARITIES

Belongs to the ABI family.

TISSUE SPECIFICITY

Widely expressed. Abundant in testes, ovary, thymus, and colon, with lower but detectable levels in prostate, peripheral blood leukocytes, and spleen.

POST-TRANSLATIONAL MODIFICATION

Phosphorylated by ABL1.

SUBCELLULAR LOCATION

Cell junction, Cell projection, Cytoplasm, Cytoskeleton, Nucleus.

FUNCTION

Regulator of actin cytoskeleton dynamics underlying cell motility and adhesion. Functions as a component of the WAVE complex, which activates actin nucleating machinery Arp2/3 to drive lamellipodia formation. Acts as regulator and substrate of nonreceptor tyrosine kinases ABL1 and ABL2 involved in processes linked to cell growth and differentiation. Positively regulates ABL1-mediated phosphorylation of ENAH, which is required for proper polymerization of nucleated actin filaments at the leading edge. Contributes to the regulation of actin assembly at the tips of neuron projections. In particular, controls dendritic spine morphogenesis and may promote dendritic spine specification toward large mushroom-type spines known as repositories of memory in the brain (By similarity). In hippocampal neurons, may mediate actin-dependent BDNF-NTRK2 early endocytic trafficking that triggers dendrite outgrowth (By similarity). Participates in ocular lens morphogenesis, likely by regulating lamellipodia-driven adherens junction formation at the epithelial cell-secondary lens fiber interface (By similarity). Also required for nascent adherens junction assembly in epithelial cells.