ACSL1 Mouse Monoclonal Antibody [A9B5] (HA601112)

UNIPROT #

P33121

PROTEIN NAME

ACSL1

SYNONYMS

ACS 1 antibody;ACS1 antibody;ACSL 1 antibody;ACSL1 antibody;ACSL1_HUMAN antibody;Acyl CoA synthetase 1 antibody;Acyl CoA synthetase long chain family member 1 antibody;Acyl-CoA synthetase 1 antibody;FACL 1 antibody;FACL 2 antibody;FACL1 antibody;FACL2 antibody;Fatty acid Coenzyme A ligase long chain 1 antibody;Fatty acid Coenzyme A ligase long chain 2 antibody;LACS 1 antibody;LACS 2 antibody;LACS antibody;LACS1 antibody;LACS2 antibody;Lignoceroyl CoA synthase antibody;Long chain acyl CoA synthetase 1 antibody;Long chain acyl CoA synthetase 2 antibody;Long chain fatty acid CoA ligase 1 antibody;Long chain fatty acid CoA ligase 2 antibody;Long chain fatty acid coenzyme A ligase 1 antibody;Long-chain acyl-CoA synthetase 1 antibody;Long-chain acyl-CoA synthetase 2 antibody;Long-chain fatty acid-CoA ligase 2 antibody;Long-chain-fatty-acid--CoA ligase 1 antibody;Palmitoyl CoA ligase 1 antibody;Palmitoyl CoA ligase 2 antibody;Palmitoyl-CoA ligase 1 antibody;Palmitoyl-CoA ligase 2 antibody;Paltimoyl CoA ligase 1 antibody

SUBCELLULAR LOCATION

Mitochondrion outer membrane, Peroxisome membrane, Microsome membrane, Endoplasmic reticulum membrane.

FUNCTION

Long-chain-fatty-acid—CoA ligase 1 is an enzyme that in humans is encoded by the ACSL1 gene. The ACSL1 gene is located on the 4th chromosome, with its specific location being 4q35.1. The gene contains 28 exons. The protein encoded by this gene is an isozyme of the long-chain fatty-acid-coenzyme A ligase family. Although differing in substrate specificity, subcellular localization, and tissue distribution, all isozymes of this family convert free long-chain fatty acids into fatty acyl-CoA esters, and thereby play a key role in lipid biosynthesis and fatty acid degradation. In melanocytic cells ACSL1 gene expression may be regulated by MITF. ACSL1 is known to be involved in fatty-acid metabolism critical for heart function and nonspecific mental retardation. Since the ACSL4 gene is highly expressed in brain, where it encodes a brain specific isoform, an ASCL1 mutation may be an efficient diagnostic tool in mentally retarded males.