ACVR2A Mouse Monoclonal Antibody [A7C8] (HA601091)

UNIPROT #

P27037

PROTEIN NAME

ACVR2A

SYNONYMS

Activin A receptor type IIA antibody;Activin receptor type 2A antibody;Activin receptor type IIA antibody;Activin receptor type-2A antibody;ACTR 2 antibody;ACTR IIA antibody;ACTR-IIA antibody;ACTR2 antibody;ACTRII antibody;ACTRIIA antibody;Acvr 2 antibody;Acvr 2A antibody;Acvr2 antibody;ACVR2A antibody;AVR2A_HUMAN antibody;OTTHUMP00000197918 antibody

SUBCELLULAR LOCATION

Membrane.

FUNCTION

This gene encodes a receptor that mediates the functions of activins, which are members of the transforming growth factor-beta (TGF-beta) superfamily involved in diverse biological processes. The encoded protein is a transmembrane serine-threonine kinase receptor which mediates signaling by forming heterodimeric complexes with various combinations of type I and type II receptors and ligands in a cell-specific manner. The encoded type II receptor is primarily involved in ligand-binding and includes an extracellular ligand-binding domain, a transmembrane domain and a cytoplasmic serine-threonine kinase domain. This gene may be associated with susceptibility to preeclampsia, a pregnancy-related disease which can result in maternal and fetal morbidity and mortality. Alternative splicing results in multiple transcript variants of this gene.