ADAM10 Rabbit Polyclonal Antibody (ER1706-97)

UNIPROT #

O14672

PROTEIN NAME

ADAM10

SYNONYMS

A disintegrin and metalloprotease domain 10 antibody;A disintegrin and metalloproteinase domain 10 antibody;AD 10 antibody;AD10 antibody;AD18 antibody;ADA10_HUMAN antibody;ADAM 10 antibody;ADAM metallopeptidase domain 10 antibody;ADAM10 antibody;CD 156c antibody;CD156c antibody;CD156c antigen antibody;CDw156 antibody;disintegrin and metalloproteinase domain containing protein 10 antibody;Disintegrin and metalloproteinase domain-containing protein 10 antibody;HsT 18717 antibody;HsT18717 antibody;Kuz antibody;Kuzbanian antibody;Kuzbanian protein homolog antibody;Kuzbanian, Drosophila, homolog of antibody;MADM antibody;Mammalian disintegrin metalloprotease antibody;Mammalian disintegrin-metalloprotease antibody;RAK antibody

TISSUE SPECIFICITY

Expressed in the brain (at protein level). Expressed in spleen, lymph node, thymus, peripheral blood leukocyte, bone marrow, cartilage, chondrocytes and fetal liver.

POST-TRANSLATIONAL MODIFICATION

The precursor is cleaved by furin and PCSK7.

SUBCELLULAR LOCATION

Golgi apparatus, Plasma membrane, Cell junction, Cell membrane, Cell projection, Cytoplasm.

FUNCTION

ADAM (a disintegrin and metalloprotease) proteins are a family of over 30 membrane-anchored, glycosylated, Zn2+ dependent proteases that are involved in cell-cell, cell-matrix interface related processes including fertilization, muscle fusion, secretion of TNFα (tumor necrosis factor α), and modulation of the neurogenic function of Notch and Delta. ADAM proteins possess a signal-domain, a pro-domain, a metalloprotease domain, a disintegrin domain (integrin ligand) a cysteine-rich region, an epidermal growth factor-like domain, a transmembrane domain and a cytoplasmic tail. ADAMs are expressed in brain, testis, epididymis, ovary, breast, placenta, liver, heart, lung, bone and muscle, and catalyze proteolysis, adhesion, fusion and intracellular signaling. ADAM10 is a TNF-processing enzyme that cleaves pro-TNF, a membrane-bound precusor protein, at Ala 76-Val 77, which causes membrane shedding of soluble TNF.