Adiponectin Recombinant Rabbit Monoclonal Antibody [PSH05-48] (HA722286)

UNIPROT #

Q15848

PROTEIN NAME

Adiponectin

SYNONYMS

30 kDa adipocyte complement related protein antibody;30 kDa adipocyte complement-related protein antibody;ACDC antibody;Acrp 30 antibody;ACRP30 antibody;ADIPO_HUMAN antibody;Adipocyte antibody;Adipocyte C1q and collagen domain containing protein antibody;Adipocyte complement related 30 kDa protein antibody;Adipocyte complement related protein of 30 kDa antibody;Adipocyte complement-related 30 kDa protein antibody;adipocyte-specific secretory protein antibody;Adiponectin antibody;Adiponectin precursor antibody;adiponectin, C1Q and collagen domain containing antibody;Adipoq antibody;Adipose most abundant gene transcript 1 antibody;Adipose most abundant gene transcript 1 protein antibody;Adipose specific collagen like factor antibody;ADIPQTL1 antibody;ADPN antibody;APM 1 antibody;apM-1 antibody;APM1 antibody;C1q and collagen domain-containing protein antibody;GBP 28 antibody;GBP28 antibody;Gelatin binding protein antibody;Gelatin binding protein 28 antibody;gelatin-binding protein 28 antibody;Gelatin-binding protein antibody;OTTHUMP00000210047 antibody

SUBCELLULAR LOCATION

Secreted.

FUNCTION

Adiponectin is a protein hormone that modulates a number of metabolic processes, including glucose regulation and fatty acid oxidation. Adiponectin is secreted from adipose tissue (and also from the placenta in pregnancy) into the bloodstream and is very abundant in plasma relative to many hormones. High adiponectin levels correlate with a lower risk of diabetes mellitus type 2. Plasma levels of adiponectin are lower in obese subjects than in lean subjects. Many studies have found adiponectin to be inversely correlated with body mass index in patient populations. However, a meta analysis was not able to confirm this association in healthy adults. Circulating adiponectin concentrations increase during caloric restriction in animals and humans, such as in patients with anorexia nervosa. Furthermore, a recent study suggests that adipose tissue within bone marrow, which increases during caloric restriction, contributes to elevated circulating adiponectin in this context.