Adipose Triglyceride Lipase Rabbit Polyclonal Antibody (HA500301)

UNIPROT #

Q96AD5

PROTEIN NAME

Adipose Triglyceride Lipase

SYNONYMS

1110001C14Rik antibody;Adipose triglyceride lipase antibody;ATGL antibody;ATGL DESNUTRIN antibody;Calcium independent phospholipase A2 antibody;Calcium-independent phospholipase A2 antibody;Desnutrin antibody;EC 3.1.1.3 antibody;FP17548 antibody;IPLA2 zeta antibody;IPLA2-zeta antibody;Mutant patatin like phospholipase domain containing 2 antibody;Patatin like phospholipase domain containing 2 antibody;PATATIN LIKE PHOSPHOLIPASE DOMAIN CONTAINING PROTEIN 2 antibody;Patatin-like phospholipase domain-containing protein 2 antibody;PEDF R antibody;PHOSPHOLIPASE A2 CALCIUM INDEPENDENT ZETA antibody;Pigment epithelium derived factor antibody;Pigment epithelium-derived factor antibody;plpl antibody;plpl2 antibody;PLPL2_HUMAN antibody;Pnpla2 antibody;Transport secretion protein 2 antibody;Transport secretion protein 2.2 antibody;Transport-secretion protein 2 antibody;Triglyceride hydrolase antibody;TTS 2.2 antibody;TTS2 antibody;TTS2.2 antibody;ZETA antibody

SUBCELLULAR LOCATION

Cell membrane, Lipid droplet.

FUNCTION

This gene encodes an enzyme which catalyzes the first step in the hydrolysis of triglycerides in adipose tissue. Mutations in this gene are associated with neutral lipid storage disease with myopathy. Catalyzes the initial step in triglyceride hydrolysis in adipocyte and non-adipocyte lipid droplets. Exhibits a strong preference for the hydrolysis of long-chain fatty acid esters at the sn-2 position of the glycerol backbone. Also has acylglycerol transacylase activity. Acts coordinately with LIPE/HLS and DGAT2 within the lipolytic cascade. Transfers fatty acid from triglyceride to retinol, hydrolyzes retinylesters, and generates 1,3-diacylglycerol from triglycerides. Regulates adiposome size and may be involved in the degradation of adiposomes. May play an important role in energy homeostasis. May play a role in the response of the organism to starvation, enhancing hydrolysis of triglycerides and providing free fatty acids to other tissues to be oxidized in situations of energy depletion.