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AKR1B1 Rabbit Polyclonal Antibody (ER2001-28)

Price: Regular price $315.00

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Catalog# ER2001-28

Rabbit Polyclonal to AKR1B1

Tested for

  • WB

  • IF-Cell

  • IHC-P

Reacts with

  • Human

  • Mouse

  • Rat

  • Zebrafish

Specifications

Product Type

Rabbit polyclonal primary

Product Name

AKR1B1 Rabbit Polyclonal Antibody (ER2001-28)

Immunogen

Synthetic peptide within human akr1b1 aa 200-260.

Host

Rabbit

Positive Control

A549 cell lysate, Siha cell lysate, Siha, human seminal vesicle tissue.

Conjugation

Unconjugated

Clonality

Polyclonal

RRID

AB_3069506

APPLICATION DILUTION

  • WB

  • 1:500-1:1,000

  • IF-Cell

  • 1:50-1:200

  • IHC-P

  • 1:100-1:500

PROPERTIES

Form

Liquid

Storage Condition

Store at +4C after thawing. Aliquot store at -20C. Avoid repeated freeze / thaw cycles.

Storage Buffer

1*TBS (pH7.4), 0.2% BSA, 50% Glycerol. Preservative: 0.05% Sodium Azide.

Concentration

1ug/ul

Purification

Protein A affinity purified.

Molecular Weight

36 kDa

Isotype

IgG

TARGET

UNIPROT #

P15121

PROTEIN NAME

AKR1B1

SYNONYMS

ADR antibody;AKR1B 1 antibody;Akr1b1 antibody;Aldehyde reductase 1 antibody;Aldehyde reductase antibody;Aldo keto reductase family 1, member B1 antibody;Aldo-keto reductase family 1 member B1 antibody;aldo-keto reductase family 1, member B1 (aldose reductase) antibody;Aldose reductase antibody;aldr 1 antibody;ALDR_HUMAN antibody;aldr1 antibody;ALR2 antibody;AR antibody;Lii5 2 CTCL tumor antigen antibody;Low Km aldose reductase antibody;MGC1804 antibody

SUBCELLULAR LOCATION

Cytoplasm.

FUNCTION

Catalyzes the NADPH-dependent reduction of a wide variety of carbonyl-containing compounds to their corresponding alcohols. Displays enzymatic activity towards endogenous metabolites such as aromatic and aliphatic aldehydes, ketones, monosacharides, bile acids and xenobiotics substrates. Key enzyme in the polyol pathway, catalyzes reduction of glucose to sorbitol during hyperglycemia . Reduces steroids and their derivatives and prostaglandins. Displays low enzymatic activity toward all-trans-retinal, 9-cis-retinal, and 13-cis-retinal . Catalyzes the reduction of diverse phospholipid aldehydes such as 1-palmitoyl-2-(5-oxovaleroyl)-sn -glycero-3-phosphoethanolamin (POVPC) and related phospholipid aldehydes that are generated from the oxydation of phosphotidylcholine and phosphatdyleethanolamides. Plays a role in detoxifying dietary and lipid-derived unsaturated carbonyls, such as crotonaldehyde, 4-hydroxynonenal, trans-2-hexenal, trans-2,4-hexadi

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