AKR1C1 Rabbit Polyclonal Antibody (R1512-11)

UNIPROT #

Q04828

PROTEIN NAME

AKR1C1

SYNONYMS

2-dihydrobenzene-1 antibody;2-diol dehydrogenase antibody;20 alpha (3 alpha) hydroxysteroid dehydrogenase antibody 20 ALPHA HSD antibody;20 alpha hydroxysteroid dehydrogenase antibody;20-alpha-HSD antibody;20-alpha-hydroxysteroid dehydrogenase antibody;20ALPHAHSD antibody;2ALPHAHSD antibody;AK1C1 antibody;AK1C1_HUMAN antibody;AKR1C1 antibody;Aldo keto reductase family 1 member C1 antibody;aldo-keto reductase C antibody;Aldo-keto reductase family 1 member C1 antibody;Aldo-keto reductase family, 1 member 1 antibody;C9 antibody;Chlordecone reductase homolog antibody;Chlordecone reductase homolog HAKRC antibody;DD1 antibody;DD1/DD2 antibody;DDH antibody;DDH1 antibody;Dihydrodiol dehydrogenase 1 antibody;Dihydrodiol dehydrogenase 1/2 antibody;dihydrodiol dehydrogenase 1; 20-alpha (3-alpha)-hydroxysteroid dehydrogenase antibody;dihydrodiol dehydrogenase isoform DD1 antibody;Dihydrodiol dehydrogenase, type 1 antibody;H37 antibody;HAKRC antibody;HBAB antibody;Hepatic dihydrodiol dehydrogenase antibody;High affinity hepatic bile acid-binding protein antibody;High-affinity hepatic bile acid-binding protein antibody;Indanol dehydrogenase antibody;MBAB antibody;MGC8954 antibody;Trans-1 antibody;Trans-1,2 dihydrobenzene 1,2 diol dehydrogenase antibody;Type II 3 alpha hydroxysteroid dehydrogenase antibody

SEQUENCE SIMILARITIES

Belongs to the aldo/keto reductase family.

TISSUE SPECIFICITY

Expressed in all tissues tested including liver, prostate, testis, adrenal gland, brain, uterus, mammary gland and keratinocytes. Highest levels found in liver, mammary gland and brain.

SUBCELLULAR LOCATION

Cytoplasm.

FUNCTION

Human liver contains isoforms of dihydrodiol dehydrogenase (DD1, DD2, DD3 and DD4), which belong to the aldo-oxo reductase/aldo-keto reductase (AKR) superfamily, have 20α- or 3α-hydroxysteroid dehydrogenase (HSD) activity. DD1 is also designated AKR1C1, DDH or DDH1, while DD2 also can be designated AKR1C2, dDD, BABP or DDH2. AKR1C3 and 3α-HSD are alternate designations for human DD3 (which is referred to as AKR1C18 in rodents), while DD4 also can be called AKR1C4, CD, CHDR or AKR1C6 (in rodents). DD1 and DD2 are 20α-HSDs, whereas DD3 and DD4 are the 3α-HSDs. The multiple human cytosolic dihydrodiol dehydrogenases are involved in the metabolism of xenobiotics, such as polycyclic aromatic hydrocarbons, pesticides and steroid hormones, and are responsible for the reduction of ketone-containing drugs by using NADH or NADPH as a cofactor. The 20α-HSD catalyzes the reaction of progesterone to the inactive form 20α-hydroxyprogesterone. The 3α-HSD is a cytosolic, monomeric, NADPH-dependent oxidoreductase that reduces 3-keto-5-dihydrosteroids to their tetrahydro products. DD1 and DD2 are ubiquitously expressed, whereas DD4 mRNA is restricted to the liver. DD3 is a unique enzyme that can specifically catalyze the dehydrogenation of trans-benzenedihydrodiol and trans-naphthalenedihydrodiol.