AKT2 Rabbit Polyclonal Antibody (HA500091)

UNIPROT #

P31751

PROTEIN NAME

AKT2

SYNONYMS

Akt2 antibody;AKT2_HUMAN antibody;HIHGHH antibody;Murine thymoma viral (v-akt) homolog 2 antibody;murine thymoma viral (v-akt) homolog-2 antibody;Oncogene AKT2 protein kinase B beta antibody;PKB antibody;PKB beta antibody;PKBB antibody;PKBBETA antibody;PRKBB antibody;Protein kinase Akt 2 antibody;Protein kinase Akt-2 antibody;Protein kinase B beta antibody;RAC beta antibody;rac protein kinase beta antibody;RAC-BETA antibody;RAC-beta serine/threonine-protein kinase antibody;RAC-PK-beta antibody;RACbeta antibody;v akt murine thymoma viral oncogene homolog 2 antibody;V-AKT murine thymoma viral oncogene homolog 2 antibody

SUBCELLULAR LOCATION

Nucleus, Cell membrane, Early endosome, Cytoplasm.

FUNCTION

AKT2 is one of 3 closely related serine/threonine-protein kinases (AKT1, AKT2 and AKT3) called the AKT kinase, and which regulate many processes including metabolism, proliferation, cell survival, growth and angiogenesis. This is mediated through serine and/or threonine phosphorylation of a range of downstream substrates. Over 100 substrate candidates have been reported so far, but for most of them, no isoform specificity has been reported. AKT is responsible of the regulation of glucose uptake by mediating insulin-induced translocation of the SLC2A4/GLUT4 glucose transporter to the cell surface. Phosphorylation of PTPN1 at 'Ser-50' negatively modulates its phosphatase activity preventing dephosphorylation of the insulin receptor and the attenuation of insulin signaling. Phosphorylation of TBC1D4 triggers the binding of this effector to inhibitory 14-3-3 proteins, which is required for insulin-stimulated glucose transport. One of the few specific substrates of AKT2 identified recently is PITX2. Phosphorylation of PITX2 impairs its association with the CCND1 mRNA-stabilizing complex thus shortening the half-life of CCND1. AKT2 seems also to be the principal isoform responsible of the regulation of glucose uptake.