alpha 1 Antichymotrypsin Recombinant Rabbit Monoclonal Antibody [JM83-29] (ET1705-47)

UNIPROT #

P01011

PROTEIN NAME

alpha 1 Antichymotrypsin

SYNONYMS

SERPINA3 antibody;AACT antibody;AACT_HUMAN antibody;ACT antibody;Alpha-1-antichymotrypsin His-Pro-less antibody;Antichymotrypsin antibody;Cell growth inhibiting gene 24/25 protein antibody;Cell growth-inhibiting gene 24/25 protein antibody;GIG24 antibody;GIG25 antibody;Growth inhibiting protein 24 antibody;Growth inhibiting protein 25 antibody;MGC88254 antibody;Serine (or cysteine) proteinase inhibitor clade A (alpha 1 antiproteinase, antitrypsin) member 3 antibody;Serine (or cysteine) proteinase inhibitor clade A member 3 antibody;Serine proteinase inhibitor clade A member 3 antibody;Serpin A3 antibody;Serpin family A member 3 antibody;Serpin peptidase inhibitor clade A (alpha 1 antiproteinase antitrypsin) member 3 antibody;SERPINA3 antibody

SEQUENCE SIMILARITIES

Belongs to the serpin family.

TISSUE SPECIFICITY

Plasma. Synthesized in the liver. Like the related alpha-1-antitrypsin, its concentration increases in the acute phase of inflammation or infection. Found in the amyloid plaques from the hippocampus of Alzheimer disease brains.

POST-TRANSLATIONAL MODIFICATION

N- and O-glycosylated.

SUBCELLULAR LOCATION

Secreted.

FUNCTION

Alpha 1-antichymotrypsin (symbol α1AC,[5] A1AC, or a1ACT) is an alpha globulin glycoprotein that is a member of the serpin superfamily. In humans, it is encoded by the SERPINA3 gene. Alpha 1-antichymotrypsin inhibits the activity of certain enzymes called proteases, such as cathepsin G that is found in neutrophils, and chymases found in mast cells, by cleaving them into a different shape or conformation. This activity protects some tissues, such as the lower respiratory tract, from damage caused by proteolytic enzymes. This protein is produced in the liver, and is an acute phase protein that is induced during inflammation. Deficiency of this protein has been associated with liver disease. Mutations have been identified in patients with Parkinson disease and chronic obstructive pulmonary disease. Alpha 1-antichymotrypsin is also associated with the pathogenesis of Alzheimer's disease as it enhances the formation of amyloid-fibrils in this disease.