alpha 1 Catenin Recombinant Rabbit Monoclonal Antibody [SC0619] (ET1610-46)
Catalog# ET1610-46
Rabbit Monoclonal to alpha 1 Catenin
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WB
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IF-Cell
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IF-Tissue
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IHC-P
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IP
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FC
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Human
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Mouse
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Rat
Positive control:
Lane 1: Hela cell lysate
Lane 2: HepG2 cell lysate
Lane 3: A431 cell lysate
Specifications
Product Type
Recombinant Rabbit monoclonal primary
Product Name
alpha 1 Catenin Recombinant Rabbit Monoclonal Antibody [SC0619] (ET1610-46)
Immunogen
Recombinant protein within human alpha 1 catenin aa 1-90 / 906.
Host
Rabbit
Positive Control
Hela cell lysate, HepG2 cell lysate, A431 cell lysate, mouse colon tissue, mouse prostate tissue, mouse uterus tissue, Hela.
Conjugation
Unconjugated
Clonality
Monoclonal
Clone Number
SC0619
RRID
APPLICATION DILUTION
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WB
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1:1,000-1:2,000
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IF-Cell
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1:50-1:200
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IF-Tissue
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1:50-1:200
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IHC-P
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1:50-1:200
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FC
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1:50-1:100
PROPERTIES
Form
Liquid
Storage Condition
Store at +4C after thawing. Aliquot store at -20C or -80C. Avoid repeated freeze / thaw cycles.
Storage Buffer
1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Concentration
1ug/ul
Purification
Protein A affinity purified.
Molecular Weight
100 kDa
Isotype
IgG
TARGET
UNIPROT #
PROTEIN NAME
alpha 1 Catenin
SYNONYMS
Alpha E-catenin antibody;Cadherin associated protein 102kDa antibody;Cadherin associated protein antibody;Cadherin-associated protein antibody;CAP 102 antibody;CAP102 antibody;Catenin (cadherin associated protein) alpha 1 102kDa antibody;Catenin (cadherin associated protein), alpha 1, 102kDa antibody;Catenin alpha 1 antibody;Catenin alpha-1 antibody;CTNA1_HUMAN antibody;CTNNA 1 antibody;Ctnna1 antibody;FLJ36832 antibody;FLJ52416 antibody;NY REN 13 antigen antibody;OTTHUMP00000224141 antibody;OTTHUMP00000224147 antibody;Renal carcinoma antigen NY REN 13 antibody;Renal carcinoma antigen NY-REN-13 antibody
SEQUENCE SIMILARITIES
Belongs to the vinculin/alpha-catenin family.
TISSUE SPECIFICITY
Expressed ubiquitously in normal tissues.
POST-TRANSLATIONAL MODIFICATION
Sumoylated.; Phosphorylation seems to contribute to the strength of cell-cell adhesion rather than to the basic capacity for cell-cell adhesion.
SUBCELLULAR LOCATION
Cytoplasm, Cell junction, Cell membrane.
FUNCTION
α E-catenin (also designated α-catenin; cadherin-associated protein, α1, 102 kDa; and CAP102) plays a role in E-cadherin mediated cell-cell adhesion by linking E-cadherin to the cytoskeleton via β- or γ-catenin and Actin. α E-catenin connects cell-density-dependent adherens junctions with the developmental hedgehog pathway and may provide a negative feedback loop controlling the size of developing cerebral cortex. It is abundant in neuroepithelial precursor cells in the developing cortical ventricular zone of the brain, with reduced expression in the cortical plate. α E-catenin-vinculin interactions play a role in the assembly of the apical junction complex in epithelia. Catenins generally are thought to work as connectors that anchor E-cadherin to the cytoskeletal Actin bundle through the cadherin cytoplasmic domain. Dysfunction of this adhesion complex causes dissociation of cancer cells from primary tumor nodules, thus possibly contributing to cancer invasion and metastasis.
CITATIONS
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Wang Junqi,et al
HHLA2 promotes hepatoma cell proliferation, migration, and invasion via SPP1/PI3K/AKT signaling pathway
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WB
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Mouse
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Citation
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