Alpha-2-macroglobulin Mouse Monoclonal Antibody [8-B10] (M1510-23)

UNIPROT #

P01023

PROTEIN NAME

Alpha-2-macroglobulin

SYNONYMS

A2m antibody;A2MG_HUMAN antibody;Alpha 2 M antibody;Alpha 2M antibody;Alpha-2-M antibody;Alpha-2-macroglobulin antibody;C3 and PZP-like alpha-2-macroglobulin domain-containing protein 5 antibody;CPAMD5 antibody;DKFZp779B086 antibody;FWP007 antibody;S863 7 antibody

SEQUENCE SIMILARITIES

Belongs to the protease inhibitor I39 (alpha-2-macroglobulin) family.

TISSUE SPECIFICITY

Secreted in plasma.

DEVELOPMENTAL STAGE

Unlike the rat protein, which is an acute phase protein, this protein is always in circulation at high levels.

SUBCELLULAR LOCATION

Secreted.

FUNCTION

Is able to inhibit all four classes of proteinases by a unique 'trapping' mechanism. This protein has a peptide stretch, called the 'bait region' which contains specific cleavage sites for different proteinases. When a proteinase cleaves the bait region, a conformational change is induced in the protein which traps the proteinase. The entrapped enzyme remains active against low molecular weight substrates (activity against high molecular weight substrates is greatly reduced). Following cleavage in the bait region, a thioester bond is hydrolyzed and mediates the covalent binding of the protein to the proteinase.