Annexin A1 Rabbit Polyclonal Antibody (ER1803-70)

UNIPROT #

P04083

PROTEIN NAME

Annexin A1

SYNONYMS

Annexin 1 antibody;Annexin A1 antibody;Annexin I (lipocortin I) antibody;Annexin I antibody;Annexin-1 antibody;AnnexinA1 antibody;AnnexinI antibody;ANX 1 antibody;ANX A1 antibody;ANX1 antibody;ANXA 1 antibody;ANXA1 antibody;ANXA1 protein antibody;ANXA1_HUMAN antibody;Calpactin 2 antibody;Calpactin II antibody;Calpactin-2 antibody;CalpactinII antibody;Chromobindin 9 antibody;Chromobindin-9 antibody;Chromobindin9 antibody;HGNC:533 antibody;Lipocortin 1 antibody;Lipocortin I antibody;Lipocortin1 antibody;LipocortinI antibody;LPC 1 antibody;LPC1 antibody;p35 antibody;Phospholipase A2 inhibitory protein antibody

SEQUENCE SIMILARITIES

Belongs to the annexin family.

TISSUE SPECIFICITY

Detected in resting neutrophils. Detected in peripheral blood T-cells. Detected in extracellular vesicles in blood serum from patients with inflammatory bowel disease, but not in serum from healthy donors. Detected in placenta (at protein level). Detected in liver.

POST-TRANSLATIONAL MODIFICATION

Phosphorylated by protein kinase C, EGFR and TRPM7. Phosphorylated in response to EGF treatment.; Sumoylated.

SUBCELLULAR LOCATION

Cell membrane, Cell projection, Cilium, Cytoplasm, Cytoplasmic vesicle, Endosome, Membrane, Nucleus, Secreted.

FUNCTION

Plays important roles in the innate immune response as effector of glucocorticoid-mediated responses and regulator of the inflammatory process. Has anti-inflammatory activity. Plays a role in glucocorticoid-mediated down-regulation of the early phase of the inflammatory response. Promotes resolution of inflammation and wound healing. Functions at least in part by activating the formyl peptide receptors and downstream signaling cascades. Promotes chemotaxis of granulocytes and monocytes via activation of the formyl peptide receptors. Contributes to the adaptive immune response by enhancing signaling cascades that are triggered by T-cell activation, regulates differentiation and proliferation of activated T-cells. Promotes the differentiation of T-cells into Th1 cells and negatively regulates differentiation into Th2 cells. Has no effect on unstimulated T cells. Promotes rearrangement of the actin cytoskeleton, cell polarization and cell migration. Negatively regulates hormone exocytosis via activation of the formyl peptide receptors and reorganization of the actin cytoskeleton. Has high affinity for Ca2+ and can bind up to eight Ca2+ ions. Displays Ca2+-dependent binding to phospholipid membranes. Plays a role in the formation of phagocytic cups and phagosomes. Plays a role in phagocytosis by mediating the Ca2+-dependent interaction between phagosomes and the actin cytoskeleton.