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Atg7 Recombinant Rabbit Monoclonal Antibody [SC06-30] (ET1610-53)

Price: Regular price $385.00

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Catalog# ET1610-53

Rabbit Monoclonal to Atg7

Tested for

  • WB

  • IF-Tissue

  • IHC-P

  • IP

  • FC

Reacts with

  • Human

  • Rat

Recombinant production enables lot-to-lot consistency and is animal-cruelty-free
Knock-Out or Knock-Down validated
This product has been cited in peer reviewed publications, see list HERE

Safety datasheet

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Specifications

Product Type

Recombinant Rabbit monoclonal primary

Product Name

Atg7 Recombinant Rabbit Monoclonal Antibody [SC06-30] (ET1610-53)

Immunogen

Synthetic peptide within human atg7 aa 654-703 / 703.

Host

Rabbit

Positive Control

HeLa cell lysate, Jurkat cell lysate, THP-1 cell lysate, human tonsil tissue, human spleen tissue, human kidney tissue, human liver tissue, rat kidney tissue lysate.

Conjugation

Unconjugated

Clonality

Monoclonal

Clone Number

SC06-30

RRID

AB_3069938

APPLICATION DILUTION

  • WB

  • 1:500-1:2,000

  • IF-Tissue

  • 1:50-1:200

  • IHC-P

  • 1:50-1:1,000

  • FC

  • 1:50-1:100

  • IP

  • Use at an assay dependent concentration.

PROPERTIES

Form

Liquid

Storage Condition

Store at +4C after thawing. Aliquot store at -20C or -80C. Avoid repeated freeze / thaw cycles.

Storage Buffer

1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.

Concentration

1ug/ul

Purification

Protein A affinity purified.

Molecular Weight

Predicted band size: 78 kDa

Isotype

IgG

TARGET

UNIPROT #

O95352

PROTEIN NAME

Atg7

SYNONYMS

1810013K23Rik antibody;Apg 7 antibody;APG7 autophagy 7 like antibody;APG7 autophagy 7-like (S. cerevisiae) antibody;APG7 like antibody;APG7, S. cerevisiae, homolog of antibody;APG7-like antibody;APG7L antibody;ATG 7 antibody;ATG12-activating enzyme E1 ATG7 antibody;ATG7 antibody;ATG7 autophagy related 7 homolog (S. cerevisiae) antibody;ATG7 autophagy related 7 homolog antibody;ATG7_HUMAN antibody;Atg7l antibody;Autophagy 7, S. cerevisiae, homolog of antibody;Autophagy related protein 7 antibody;Autophagy-related 7 (yeast) antibody;Autophagy-related protein 7 antibody;DKFZp434N0735 antibody;GSA 7 antibody;GSA7 antibody;hAGP7 antibody;Ubiquitin activating enzyme E1 like protein antibody;Ubiquitin-activating enzyme E1-like protein antibody;Ubiquitin-like modifier-activating enzyme ATG7 antibody

SEQUENCE SIMILARITIES

Belongs to the ATG7 family.

TISSUE SPECIFICITY

Widely expressed, especially in kidney, liver, lymph nodes and bone marrow.

POST-TRANSLATIONAL MODIFICATION

Acetylated by EP300.

SUBCELLULAR LOCATION

Cytoplasm.

FUNCTION

E1-like activating enzyme involved in the 2 ubiquitin-like systems required for cytoplasm to vacuole transport (Cvt) and autophagy. Activates ATG12 for its conjugation with ATG5 as well as the ATG8 family proteins for their conjugation with phosphatidylethanolamine. Both systems are needed for the ATG8 association to Cvt vesicles and autophagosomes membranes. Required for autophagic death induced by caspase-8 inhibition. Required for mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to fulfill cellular energy requirements and preventing excess ROS production. Modulates p53/TP53 activity to regulate cell cycle and survival during metabolic stress. Plays also a key role in the maintenance of axonal homeostasis, the prevention of axonal degeneration, the maintenance of hematopoietic stem cells, the formation of Paneth cell granules, as well as in adipose differentiation. Plays a role in regulating the liver clock and glucose metabolism by mediating the autophagic degradation of CRY1 (clock repressor) in a time-dependent manner.

CITATIONS

  • Li, D., Liu, Y., Zhan, Q., Zeng, Y., Peng, Z., He, Q., Tan, Q., Cao, W., Wang, S., & Wang, J.

    Astragaloside IV Blunts Epithelial-Mesenchymal Transition and G2/M Arrest to Alleviate Renal Fibrosis via Regulating ALDH2-Mediated Autophagy

  • Peng, S. Z., Chen, X. H., Chen, S. J., Zhang, J., Wang, C. Y., Liu, W. R., Zhang, D., Su, Y., & Zhang, X. K.

    Phase separation of Nur77 mediates celastrol-induced mitophagy by promoting the liquidity of p62/SQSTM1 condensates

  • Shi Yan,et al

    Exosomal miR-4645-5p from hypoxic bone marrow mesenchymal stem cells facilitates diabetic wound healing by restoring keratinocyte autophagy

  • Shi, Y., Wang, S., Zhang, W., Zhu, Y., Fan, Z., Huang, Y., Li, F., & Yang, R.

    Bone marrow mesenchymal stem cells facilitate diabetic wound healing through the restoration of epidermal cell autophagy via the HIF-1α/TGF-β1/SMAD pathway

  • Deng, T., Hu, B., Wang, X., Ding, S., Lin, L., Yan, Y., Peng, X., Zheng, X., Liao, M., Jin, Y., Dong, W., Gu, J., & Zhou, J.

    TRAF6 autophagic degradation by avibirnavirus VP3 inhibits antiviral innate immunity via blocking NFKB/NF-κB activation

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