APRIL/TNFSF13 Recombinant Rabbit Monoclonal Antibody [JE49-07] (ET7109-89)

UNIPROT #

O75888

PROTEIN NAME

APRIL/TNFSF13

SYNONYMS

A proliferation inducing ligand antibody;A proliferation-inducing ligand antibody;APRIL antibody;CD256 antibody;TALL-2 antibody;TALL2 antibody;TNF related death ligand antibody;TNF- and APOL-related leukocyte expressed ligand 2 antibody;TNF-related death ligand 1 antibody;TNF13_HUMAN antibody;TNFSF13 antibody;TRDL-1 antibody;TRDL1 antibody;Tumor necrosis factor (ligand) superfamily, member 13 antibody;Tumor necrosis factor ligand superfamily member 13 antibody;Tumor necrosis factor like protein ZTNF2 antibody;Tumor necrosis factor related death ligand 1 antibody;UNQ383/PRO715 antibody;ZTNF2 antibody

SEQUENCE SIMILARITIES

Belongs to the tumor necrosis factor family.

TISSUE SPECIFICITY

Expressed at high levels in transformed cell lines, cancers of colon, thyroid, lymphoid tissues and specifically expressed in monocytes and macrophages.

POST-TRANSLATIONAL MODIFICATION

The precursor is cleaved by furin.

SUBCELLULAR LOCATION

Secreted.

FUNCTION

A proliferation-inducing ligand (APRIL), also known as tumor necrosis factor ligand superfamily member 13 (TNFSF13), is a protein of the TNF superfamily recognized by the cell surface receptor TACI. The protein encoded by this gene is a member of the tumor necrosis factor ligand (TNF) ligand family. This protein is a ligand for TNFRSF17/BCMA, a member of the TNF receptor family. This protein and its receptor are both found to be important for B cell development. In vivo experiments suggest an important role for APRIL in the long-term survival of plasma cells in the bone marrow. Mice deficient in APRIL have normal immune system development. However, APRIL-deficient mice have also been reported to possess a reduced ability to support plasma cell survival. In vitro experiments suggested that this protein may be able to induce apoptosis through its interaction with other TNF receptor family proteins such as TNFRSF6/FAS and TNFRSF14/HVEM. Three alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported.