ASGPR1 Recombinant Rabbit Monoclonal Antibody [PSH06-01] (HA722500)

UNIPROT #

P07306

PROTEIN NAME

ASGPR1

SYNONYMS

ASGP-R 1 antibody;ASGPR 1 antibody;ASGPR antibody;ASGPR1 antibody;Asgr1 antibody;ASGR1_HUMAN antibody;Asialoglycoprotein receptor 1 antibody;C type lectin domain family 4 member H1 antibody;C-type lectin domain family 4 member H1 antibody;CLEC4H1 antibody;Hepatic lectin H1 antibody;HL-1 antibody

SUBCELLULAR LOCATION

Membrane; Secreted.

FUNCTION

Asialoglycoprotein receptor 1 is a protein that in humans is encoded by the ASGR1 gene. This gene encodes a subunit of the asialoglycoprotein receptor. This receptor is a transmembrane protein that plays a critical role in serum glycoprotein homeostasis by mediating the endocytosis and lysosomal degradation of glycoproteins with exposed terminal galactose or N-acetylgalactosamine residues. The asialoglycoprotein receptor may facilitate hepatic infection by multiple viruses including hepatitis B, and is also a target for liver-specific drug delivery. The asialoglycoprotein receptor is a hetero-oligomeric protein composed of major and minor subunits, which are encoded by different genes. The protein encoded by this gene is the more abundant major subunit. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.