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ASH2L Rabbit Polyclonal Antibody (R1408-1)

Price: Regular price $315.00

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Catalog# R1408-1

Rabbit Polyclonal to ASH2L

Tested for

  • WB

  • IHC-P

  • FC

Reacts with

  • Human

  • Mouse

  • Rat

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Specifications

Product Type

Rabbit polyclonal primary

Product Name

ASH2L Rabbit Polyclonal Antibody (R1408-1)

Immunogen

Synthetic peptide within human ash2l aa 575-628.

Host

Rabbit

Positive Control

Hela cell lysates, PC-12 cell lysates, mouse colon tissue, human breast carcinoma tissue, human colon tissue, Siha.

Conjugation

Unconjugated

Clonality

Polyclonal

RRID

AB_3073299

APPLICATION DILUTION

  • WB

  • 1:500-1:1,000

  • IHC-P

  • 1:100-1:500

  • FC

  • 1:50-1:100

PROPERTIES

Form

Liquid

Storage Condition

Store at +4C after thawing. Aliquot store at -20C. Avoid repeated freeze / thaw cycles.

Storage Buffer

1*TBS (pH7.4), 0.2% BSA, 50% Glycerol. Preservative: 0.05% Sodium Azide.

Concentration

1ug/ul

Purification

Immunogen affinity purified.

Molecular Weight

59/57/60

Isotype

IgG

TARGET

UNIPROT #

Q9UBL3

PROTEIN NAME

ASH2L

SYNONYMS

ASH 2 antibody;Ash2 (absent small or homeotic) like antibody;Ash2 (absent, small, or homeotic) like (Drosophila) antibody;ASH2 antibody;ASH2 LIKE antibody;ASH2 like protein antibody;ASH2-like protein antibody;Ash2l antibody;ASH2L_HUMAN antibody;ASH2L1 antibody;ASH2L2 antibody;Bre 2 antibody;Bre2 antibody;Discs 2-like antibody;Drosophila absent, small, or homeotic antibody;Drosophila ASH2-like antibody;Set1/Ash2 histone methyltransferase complex subunit ASH2 antibody

SUBCELLULAR LOCATION

Nucleus.

FUNCTION

Transcriptional regulator . Component or associated component of some histone methyltransferase complexes which regulates transcription through recruitment of those complexes to gene promoters . Component of the Set1/Ash2 histone methyltransferase (HMT) complex, a complex that specifically methylates 'Lys-4' of histone H3, but not if the neighboring 'Lys-9' residue is already methylated. As part of the MLL1/MLL complex it is involved in methylation and dimethylation at 'Lys-4' of histone H3 . May play a role in hematopoiesis (PubMed:12670868). In association with RBBP5 and WDR5, stimulates the histone methyltransferase activities of KMT2A, KMT2B, KMT2C, KMT2D, SETD1A and SETD1B .

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