ASH2L Rabbit Polyclonal Antibody (R1408-1)

UNIPROT #

Q9UBL3

PROTEIN NAME

ASH2L

SYNONYMS

ASH 2 antibody;Ash2 (absent small or homeotic) like antibody;Ash2 (absent, small, or homeotic) like (Drosophila) antibody;ASH2 antibody;ASH2 LIKE antibody;ASH2 like protein antibody;ASH2-like protein antibody;Ash2l antibody;ASH2L_HUMAN antibody;ASH2L1 antibody;ASH2L2 antibody;Bre 2 antibody;Bre2 antibody;Discs 2-like antibody;Drosophila absent, small, or homeotic antibody;Drosophila ASH2-like antibody;Set1/Ash2 histone methyltransferase complex subunit ASH2 antibody

SUBCELLULAR LOCATION

Nucleus.

FUNCTION

Transcriptional regulator . Component or associated component of some histone methyltransferase complexes which regulates transcription through recruitment of those complexes to gene promoters . Component of the Set1/Ash2 histone methyltransferase (HMT) complex, a complex that specifically methylates 'Lys-4' of histone H3, but not if the neighboring 'Lys-9' residue is already methylated. As part of the MLL1/MLL complex it is involved in methylation and dimethylation at 'Lys-4' of histone H3 . May play a role in hematopoiesis (PubMed:12670868). In association with RBBP5 and WDR5, stimulates the histone methyltransferase activities of KMT2A, KMT2B, KMT2C, KMT2D, SETD1A and SETD1B .