ATG12 Mouse Monoclonal Antibody [1-11] (M1701-4)

UNIPROT #

O94817

PROTEIN NAME

ATG12

SYNONYMS

APG12-like antibody;APG12L antibody;ATG12 antibody;ATG12 autophagy related 12 homolog (S. cerevisiae) antibody;ATG12 autophagy related 12 homolog antibody;ATG12_HUMAN antibody;Autophagy 12 antibody;Autophagy-related protein 12 antibody;FBR93 antibody;HAPG12 antibody;Ubiquitin-like protein ATG12 antibody

SEQUENCE SIMILARITIES

Belongs to the ATG12 family.

TISSUE SPECIFICITY

Ubiquitous.

POST-TRANSLATIONAL MODIFICATION

Acetylated by EP300.

SUBCELLULAR LOCATION

Cytoplasm. Membrane.

FUNCTION

Atg12 (autophagy-related protein 12), also known as APG12, APG12L, FBR93 or HAPG12, is a 140 amino acid protein that is ubiquitously expressed and belongs to the Atg12 family of proteins. Atg12 is a homolog of the yeast protein Apg12 that participates in autophagy. Autophagy is a membrane trafficking mechanism that delivers cytoplasmic cargo to the vacuole/lysosome for degradation and recycling. In yeast, autophagy requires a protein conjugation system consisting of Apg12 covalently bound at the carboxy terminal glycine to lysine 149 of Apg5. Similarly in humans, Atg12 is essential for autophagy and localizes to the cytoplasm where it is covalently bound to APG5, a conjugation reaction that requires APG7, Atg10 and ATP. The Atg12-APG5 conjugate functions as an important regulator of the autophagic process and is required for the change in membrane morphology and development of autophagosomes. Due to alternative splicing events, two Atg12 isoforms exist.