AXL Rabbit Polyclonal Antibody (R1406-3)

UNIPROT #

P30530

PROTEIN NAME

AXL

SYNONYMS

Adhesion related kinase antibody;AI323647 antibody;Ark antibody;Axl antibody;AXL oncogene antibody;AXL receptor tyrosine kinase antibody;AXL transforming gene antibody;AXL transforming sequence/gene antibody;EC 2.7.10.1 antibody;JTK11 antibody;Oncogene AXL antibody;Tyro7 antibody;Tyrosine protein kinase receptor UFO antibody;Tyrosine-protein kinase receptor UFO antibody;UFO antibody;UFO_HUMAN antibody

SEQUENCE SIMILARITIES

Belongs to the protein kinase superfamily. Tyr protein kinase family. AXL/UFO subfamily.

TISSUE SPECIFICITY

Highly expressed in metastatic colon tumors. Expressed in primary colon tumors. Weakly expressed in normal colon tissue.

POST-TRANSLATIONAL MODIFICATION

Monoubiquitinated upon GAS6-binding. A very small proportion of the receptor could be subjected to polyubiquitination in a very transient fashion.; Phosphorylated at tyrosine residues by autocatalysis, which activates kinase activity.

SUBCELLULAR LOCATION

Cell membrane.

FUNCTION

The AXL receptor transduces signals from the extracellular matrix into the cytoplasm by binding growth factors like vitamin K-dependent protein growth-arrest-specific gene 6 (GAS6). It is involved in the stimulation of cell proliferation and survival. Proteolytic cleavage of the AXL extracellular domain by the metalloproteinases ADAM10 and ADAM17 can downregulate this signalling activity. Signalling pathways activated downstream of AXL include PI3K-AKT-mTOR, MEKERK, NF-κB, and JAK/STAT. This receptor can also mediate cell aggregation by homophilic binding. AXL protein is expressed in normal tissues, particularly in bone marrow stroma and myeloid cells, and in tumour cells and tumour vasculature. In cancer, AXL is expressed on the tumor cells as well as adjacent immune cells including dendritic cells, macrophages, and NK cells. Axl is an inhibitor of the innate immune response. The function of activated AXL in normal tissues includes the efficient clearance of apoptotic material and the dampening of TLR-dependent inflammatory responses and natural killer cell activity. AXL is a putative driver of diverse cellular processes that are critical for the development, growth, and spread of tumours, including proliferation, invasiveness and migration, epithelial-to-mesenchymal transition, stemness, angiogenesis, and immune modulation. AXL has been implicated as a cancer driver and correlated with poor survival in numerous aggressive tumors including triple-negative breast cancer (TNBC), acute myeloid leukemia (AML), non-small-cell lung cancer (NSCLC), pancreatic cancer and ovarian cancer, among others.