BAF57 Recombinant Rabbit Monoclonal Antibody [JE41-11] (ET7109-23)

UNIPROT #

Q969G3

PROTEIN NAME

BAF57

SYNONYMS

BAF57 antibody;BRG1 associated factor 57 antibody;BRG1-associated factor 57 antibody;Chromatin remodeling complex BRG1 associated factor 57 antibody;FLJ35648 antibody;SMARCE 1 antibody;SMARCE1 antibody;SMCE1_HUMAN antibody;SWI/SNF related matrix associated actin dependent regulator of chromatin e1 antibody;SWI/SNF related matrix associated actin dependent regulator of chromatin subfamily e member 1 antibody;SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1 antibody

POST-TRANSLATIONAL MODIFICATION

Ubiquitinated by TRIP12, leading to its degradation by the proteasome. Ubiquitination is prevented upon interaction between TRIP12 and SMARCC1.

SUBCELLULAR LOCATION

Nucleus.

FUNCTION

The SWI/SNF complex is involved in the activation of transcription via the remodeling of nucleosome structure in an ATP-dependent manner. Brm (also designated SNF1 or SNF2α) and Brg-1 (also designated SNF2 or SNF2β) are the ATPase subunits of the mammalian SWI/SNF complex. Brm, Brg-1, Ini1 (integrase interactor 1, also designated SNF5), BAF155 (also designated SRG3) and BAF170 are thought to comprise the functional core of the SWI/SNF complex. In higher eukaryotes, BAF57 is also a critical component of the SWI/ SNF complex. BAF57 contains a high-mobility-group (HMG) domain adjacent to a kinesin-like region and is a DNA-binding subunit of the SWI/SNF complex. The human BAF57 gene maps within the q12-25 region of chromosome 17, a gene-rich area implicated in breast and ovarian cancers.