BAP31 Recombinant Rabbit Monoclonal Antibody [JG37-81] (ET7108-54)

UNIPROT #

P51572

PROTEIN NAME

BAP31

SYNONYMS

6C6 AG antibody;6C6 AG tumor associated antigen antibody;6C6-AG tumor-associated antigen antibody;6C6AG antibody;6C6AG tumor associated antigen antibody;Accessory protein BAP 31 antibody;Accessory protein BAP31 antibody;B cell receptor associated protein 31 antibody;B-cell receptor-associated protein 31 antibody;BA31 antibody;BAP 31 antibody;Bap31 antibody;BAP31_HUMAN antibody;BCAP 31 antibody;BCAP31 antibody;BCR associated protein Bap 31 antibody;BCR associated protein Bap31 antibody;BCR-associated protein 31 antibody;CDM antibody;CDM protein antibody;DXS1357E antibody;MS950 antibody;p28 antibody;p28 Bap31 antibody;Protein CDM antibody;RP23-329M9.5 antibody

SEQUENCE SIMILARITIES

Belongs to the BCAP29/BCAP31 family.

TISSUE SPECIFICITY

Ubiquitous. Highly expressed in neurons and discrete endocrine cells.

POST-TRANSLATIONAL MODIFICATION

Cleaved by CASP8 and other caspases.

SUBCELLULAR LOCATION

Endoplasmic reticulum membrane.

FUNCTION

BAP31, a human Bcl-2-interacting protein, is an integral membrane protein that is a component of a protein complex in the endoplasmic reticulum. This protein complex mechanically bridges an apoptosis-initiating caspase, like procaspase-8, with the anti-apoptotic regulator Bcl-2 or Bcl-XL. The cytosolic domain of BAP31 contains two identical caspase recognition sites, which are preferentially cleaved by initiator caspases, including caspase 8. Cleavage of BAP31 during apoptosis generates a p20 fragment, which remains integrated in the membrane and, when expressed ectopically, is a potent inducer of cell death. BAP31 cleavage is important for manifesting cytoplasmic apoptotic events associated with membrane fragmentation and in the cross talk between mitochondria and the endoplasmic reticulum during Fas- mediated apoptosis. The BAP31 gene is ubiquitously expressed in murine tissues and is located on the X chromosome in both mouse and human.