BAX Rabbit Polyclonal Antibody (R1706-19)

UNIPROT #

Q07812

PROTEIN NAME

BAX

SYNONYMS

Apoptosis regulator BAX antibody;BAX antibody;Bax-protein antibody;BAX_HUMAN antibody;BAXA antibody;Baxdelta2G9 antibody;Baxdelta2G9omega antibody;Baxdelta2omega antibody;Bcl-2-like protein 4 antibody;BCL2 associated X protein antibody;BCL2 associated X protein omega antibody;BCL2 associated X protein transcript variant delta2 antibody;Bcl2-L-4 antibody;BCL2L4 antibody;membrane isoform alpha antibody

SEQUENCE SIMILARITIES

Belongs to the Bcl-2 family.

TISSUE SPECIFICITY

Expressed in a wide variety of tissues. Isoform Psi is found in glial tumors. Isoform Alpha is expressed in spleen, breast, ovary, testis, colon and brain, and at low levels in skin and lung. Isoform Sigma is expressed in spleen, breast, ovary, testis, lung, colon, brain and at low levels in skin. Isoform Alpha and isoform Sigma are expressed in pro-myelocytic leukemia, histiocytic lymphoma, Burkitt's lymphoma, T-cell lymphoma, lymphoblastic leukemia, breast adenocarcinoma, ovary adenocarcinoma, prostate carcinoma, prostate adenocarcinoma, lung carcinoma, epidermoid carcinoma, small cell lung carcinoma and colon adenocarcinoma cell lines.

SUBCELLULAR LOCATION

Mitochondrion membrane, cytoplasm.

FUNCTION

Bax is a key component for cellular induced apoptosis through mitochondrial stress. It accelerates programmed cell death by binding to, and antagonizing the apoptosis repressor BCL2 or its adenovirus homolog E1B 19k protein. Under stress conditions, BAX undergoes a conformation change that causes translocation to the mitochondrion membrane, leading to the release of cytochrome c that then triggers apoptosis. It promotes activation of CASP3, and thereby apoptosis.