BCL2A1 Recombinant Rabbit Monoclonal Antibody [SC05-42] (ET1610-20)

UNIPROT #

Q16548

PROTEIN NAME

BCL2A1

SYNONYMS

ACC 1 antibody;ACC 2 antibody;B2LA1_HUMAN antibody;Bcl 2 related protein A1 antibody;Bcl-2-like protein 5 antibody;Bcl-2-related protein A1 antibody;BCL2 related protein A1 antibody;Bcl2-L-5 antibody;BCL2A1 antibody;BCL2L5 antibody;BFL1 antibody;GRS antibody;HBPA1 antibody;Hematopoietic BCL2 related protein A1 antibody;Hemopoietic specific early response protein antibody;Hemopoietic-specific early response protein antibody;Protein BFL 1 antibody;Protein BFL-1 antibody;Protein GRS antibody

SEQUENCE SIMILARITIES

Belongs to the Bcl-2 family.

TISSUE SPECIFICITY

Seems to be restricted to the hematopoietic compartment. Expressed in peripheral blood, spleen, and bone marrow, at moderate levels in lung, small intestine and testis, at a minimal levels in other tissues. Also found in vascular smooth muscle cells and hematopoietic malignancies.

SUBCELLULAR LOCATION

Cytoplasm.

FUNCTION

The Bcl-2 family of proteins is characterized by its ability to modulate cell death under a broad range of physiological conditions. Bcl-2 and Bcl-xL function to inhibit apoptosis while other members of the Bcl-2 family, Bax, Bad, Bak and Bcl-xS, oppose death-suppressing effects. An additional member of the family, A1 (also designated Bfl-1), dimerizes with both Bcl-2 and Bax and has been identified as a hematopoietic- specific, early inducible gene. While A1 demonstrates life promoting properties similar to those of Bcl-2, its function may be more temporally regulated during myeloid differentiation and dependent on additional growth stimuli to confer its life promoting properties. A1 is abundantly expressed in bone marrow and at low levels in other tissues. There is evidence that a correlation exists between a high expression of the A1 gene product and stomach cancer.