BLNK Recombinant Rabbit Monoclonal Antibody [JE63-50] (HA721028)

UNIPROT #

Q9QUN3

PROTEIN NAME

BLNK

SYNONYMS

AGM4 antibody;B cell adapter containing SH2 domain protein antibody;B cell adapter containing Src homology 2 domain protein antibody;B cell adaptor containing SH2 domain antibody;B cell linker antibody;B cell linker protein antibody;B cell-specific adaptor protein antibody;B-cell activation antibody;B-cell adapter containing a SH2 domain protein antibody;B-cell adapter containing a Src homology 2 domain protein antibody;B-cell linker protein antibody;BASH antibody;Bca antibody;BLNK antibody;BLNK s antibody;BLNK_HUMAN antibody;Cytoplasmic adapter protein antibody;Ly 57 antibody;Ly57 antibody;Lymphocyte antigen 57 antibody;Lyw 57 antibody;Lyw57 antibody;MGC111051 antibody;SH2 domain-containing leukocyte protein, 65-KD antibody;SLP 65 antibody;SLP-65 antibody;SLP65 antibody;Src homology [SH2] domain-containing leukocyte protein of 65 kD antibody;Src homology 2 domain containing leukocyte protein of 65 kDa antibody;Src homology 2 domain-containing leukocyte protein of 65 kDa antibody

SUBCELLULAR LOCATION

Cell membrane, Cytoplasm.

FUNCTION

The B-cell linker protein is encoded by the BLNK gene and is an adaptor protein also known as SLP-65, BASH, and BCA. BLNK is expressed in B cells and macrophages and plays a large role in B cell receptor signalling, in a fashion analogous to the role its paralogue SLP-76 plays in T cell receptor signalling. As it has no known intrinsic enzymatic activity, the function of BLNK is to temporally and spatially coordinate and regulate signalling effectors downstream of the B cell receptor. The function of BLNK was first illustrated in BLNK deficient DT40 cells, a chicken B-cell line, which exhibited an abrogated intracellular calcium mobilisation response and impaired activation of MAP kinases p38, JNK, and to a lesser degree ERK upon B-cell receptor (BCR) activation as compared to wild type DT40 cells. In knockout mice, BLNK deficiency results in a partial block in B-cell development, and in humans BLNK deficiency results in a much more profound block in B-cell development. Linker or adaptor proteins provide mechanisms by which receptors can amplify and regulate downstream effector proteins. The B-cell linker protein is essential for normal B-cell development.