Bmi1 Mouse Monoclonal Antibody [A11-C11] (EM1701-55)

UNIPROT #

P35226

PROTEIN NAME

Bmi1

SYNONYMS

B lymphoma Mo MLV insertion region (mouse) antibody;B lymphoma Mo MLV insertion region 1 homolog antibody;Bmi 1 antibody;BMI1 antibody;BMI1 polycomb ring finger oncogene antibody;BMI1_HUMAN antibody;Flvi 2/bmi 1 antibody;FLVI2/BMI1 antibody;MGC12685 antibody;Murine leukemia viral (bmi 1) oncogene homolog antibody;Oncogene BMI 1 antibody;PCGF 4 antibody;PCGF4 antibody;Polycomb complex protein BMI 1 antibody;Polycomb complex protein BMI-1 antibody;Polycomb group protein Bmi1 antibody;Polycomb group ring finger 4 antibody;Polycomb group RING finger protein 4 antibody;RING finger protein 51 antibody;RNF 51 antibody;RNF51 antibody

POST-TRANSLATIONAL MODIFICATION

Monoubiquitinated (By similarity). May be polyubiquitinated; which does not lead to proteasomal degradation.

SUBCELLULAR LOCATION

Cytoplasm. Nucleus.

FUNCTION

In Drosophila, Polycomb (Pc-g) gene family encodes chromatin proteins that are required for the repression of homeotic loci in embryonic development. Mel-18 and Bmi-1, mammalian homologs of Drosophila Pc-g group proteins, are similarly expressed during development and implicated in the regulation of gene expression, axial skeleton development, control of proliferation and survival of haematopoietic cells. Mel-18 directly binds to DNA through a RING-finger motif and preferentially associates with juxtaposed enhancer elements on various genes, including Bcl-2, c-Myc and Hox. Mel-18 is an immediate early response gene within the c-Myc/Cdc25 signaling cascade that exhibits tumor suppressor activity and negatively regulates cell cycle progression by blocking S phase entry. Alternatively, Bmi-1 has been identified as a potent oncogene as it contributes to the transcriptional activation of genes implicated in early lymphoid development. Proviral activation of Bmi-1 expression corresponds to enhanced gene-specific activation of other proto-oncogenes, including c-Myc and Pim, subsequently resulting in the progression of lymphomagenesis.