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C10orf58 Mouse Monoclonal Antibody [7-B7] (M1012-4)

Price: Regular price $350.00

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Catalog# M1012-4

Mouse Monoclonal to C10orf58

Tested for

  • WB

  • IF-Cell

Reacts with

  • Human

Specifications

Product Type

Mouse monoclonal primary

Product Name

C10orf58 Mouse Monoclonal Antibody [7-B7] (M1012-4)

Immunogen

Recombinant protein within human c10orf58 aa 1-229 / 229.

Host

Mouse

Positive Control

Recombinant protein, human skin tissue lysate, HepG2, HUVEC, PC-3M.

Conjugation

Unconjugated

Clonality

Monoclonal

Clone Number

7-B7

RRID

AB_3073036

APPLICATION DILUTION

  • WB

  • 1:500

  • IF-Cell

  • 1:50-1:200

PROPERTIES

Form

Liquid

Storage Condition

Store at +4C after thawing. Aliquot store at -20C or -80C. Avoid repeated freeze / thaw cycles.

Storage Buffer

1*PBS (pH7.4), 0.2% BSA, 50% Glycerol. Preservative: 0.05% Sodium Azide.

Concentration

2ug/ul

Purification

Protein A affinity purified.

Molecular Weight

Predicted band size: 26 kDa

Isotype

IgG2a

TARGET

UNIPROT #

Q9BRX8

PROTEIN NAME

C10orf58

SYNONYMS

C10orf58 antibody;CJ058_HUMAN antibody;UPF0765 protein C10orf58 antibody

SEQUENCE SIMILARITIES

Belongs to the peroxiredoxin-like PRXL2 family. PRXL2A subfamily.

TISSUE SPECIFICITY

Expressed in CSF1 and TNFSF11-stimulated CD14(+) peripheral blood mononuclear cells (PBMCs).

SUBCELLULAR LOCATION

Cytoplasm, Secreted.

FUNCTION

FAM213A, also known as PAMM (peroxiredoxin-like 2 activated in M-CSF stimulated monocytes) or C10orf58, is a 229 amino acid cytoplasmic protein that belongs to the peroxiredoxin-like FAM213 family and FAM213A subfamily. FAM213A involved in redox regulation of the cell. Acts as an antioxidant. Inhibits TNFSF11-induced NFKB1 and JUN activation and osteoclast differentiation. May affect bone resorption and help to maintain bone mass. Acts as a negative regulator of macrophage-mediated inflammation by inhibiting macrophage production of inflammatory cytokines, probably through suppression of the MAPK signaling pathway.

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