Calcineurin B Rabbit Polyclonal Antibody (HA500346)

UNIPROT #

P63098

PROTEIN NAME

Calcineurin B

SYNONYMS

alpha isoform (calcineurin B, type I) antibody;calcineurin B, type I (19kDa) antibody;Calcineurin subunit B type 1 antibody;CALNB1 antibody;CANB1_HUMAN antibody;Cna2 antibody;CNB antibody;CNB1 antibody;OTTHUMP00000201960 antibody;OTTHUMP00000201961 antibody;Ppp3r1 antibody;PPP3R1 protein phosphatase 3 (formerly 2B), regulatory subunit B, alpha isoform antibody;protein phosphatase3 (formerly2B), regulatory subunit B, alpha isoform antibody;Protein phosphatase 2B regulatory subunit 1 antibody;Protein phosphatase 2B regulatory subunit B alpha antibody;protein phosphatase 3 (formerly 2B), regulatory subunit B, 19kDa, alpha isoform (calcineurin B, type I) antibody;Protein phosphatase 3 (formerly 2B), regulatory subunit B (19kD), alpha isoform (calcineurin B, type I) antibody;Protein phosphatase 3 regulatory subunit B alpha antibody;Protein phosphatase 3 regulatory subunit B alpha isoform 1 antibody

SUBCELLULAR LOCATION

Cell membrane, sarcolemma, cell membrane, cytosol.

FUNCTION

Calcineurin (CaN) is a calcium and calmodulin dependent serine/threonine protein phosphatase (also known as protein phosphatase 3, and calcium-dependent serine-threonine phosphatase). It activates the T cells of the immune system and can be blocked by drugs. Calcineurin activates nuclear factor of activated T cell cytoplasmic (NFATc), a transcription factor, by dephosphorylating it. The activated NFATc is then translocated into the nucleus, where it upregulates the expression of interleukin 2 (IL-2), which, in turn, stimulates the growth and differentiation of the T cell response. Calcineurin is the target of a class of drugs called calcineurin inhibitors, which include ciclosporin, voclosporin, pimecrolimus and tacrolimus. Calcineurin inhibitors are prescribed for adult rheumatoid arthritis (RA) as a single drug or in combination with methotrexate. The microemulsion formulation is approved by the U.S. Food and Drug Administration for treatment of severely active RA. Calcineurin is linked to receptors for several brain chemicals including glutamate, dopamine and GABA. Calcineurin along with NFAT, may improve the function of diabetics' pancreatic beta cells. Calcineurin inhibitors such as tacrolimus are used to suppress the immune system in organ allotransplant recipients to prevent rejection of the transplanted tissue.