CaMKⅡ Recombinant Rabbit Monoclonal Antibody [SU03-57] (ET1608-47)

UNIPROT #

Q13554

PROTEIN NAME

CaMKⅡ

SYNONYMS

Calcium/calmodulin dependent protein kinase II alpha antibody;Calcium/calmodulin dependent protein kinase II beta antibody;Calcium/calmodulin dependent protein kinase II delta antibody;Calcium/calmodulin dependent protein kinase II gamma antibody;Calcium/calmodulin-dependent protein kinase type II subunit alpha antibody;CaM kinase II alpha antibody;CaM kinase II antibody;CaM kinase II beta antibody;CaM kinase II delta antibody;CaM kinase II gamma antibody;CaM kinase II subunit alpha antibody;CaMK-II subunit alpha antibody;CAMK2 antibody;Camk2a antibody;CAMK2B antibody;CAMK2D antibody;CAMK2G antibody;CAMKA antibody;KCC2A_HUMAN antibody;CaMKⅡ

SEQUENCE SIMILARITIES

Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily.

TISSUE SPECIFICITY

Widely expressed. Expressed in adult and fetal brain. Expression is slightly lower in fetal brain. Expressed in skeletal muscle.

POST-TRANSLATIONAL MODIFICATION

Autophosphorylation of Thr-287 following activation by Ca(2+)/calmodulin. Phosphorylation of Thr-287 locks the kinase into an activated state.

SUBCELLULAR LOCATION

Cytoplasm, Sarcoplasmic reticulum membrane, Cell membrane, Cell junction.

FUNCTION

Ca2+/calmodulin-dependent protein kinase II (CaM kinase II or CaMKII) is a serine/threonine-specific protein kinase that is regulated by the Ca2+/calmodulin complex. CaMKII is involved in many signaling cascades and is thought to be an important mediator of learning and memory. CaMKII is also necessary for Ca2+ homeostasis and reuptake in cardiomyocytes, chloride transport in epithelia, positive T-cell selection, and CD8 T-cell activation. Misregulation of CaMKII is linked to Alzheimer's disease, Angelman syndrome, and heart arrhythmia.