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CARD9 Recombinant Rabbit Monoclonal Antibody [PSH0-41] (HA721343)

Price: Regular price $385.00

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Catalog# HA721343

Rabbit Monoclonal to CARD9

Tested for

  • WB

  • IF-Cell

  • FC

Reacts with

  • Human

  • Mouse

  • Rat

Recombinant production enables lot-to-lot consistency and is animal-cruelty-free

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Specifications

Product Type

Recombinant Rabbit monoclonal primary

Product Name

CARD9 Recombinant Rabbit Monoclonal Antibody [PSH0-41] (HA721343)

Immunogen

Recombinant protein within human card9 aa 1-200 / 536.

Host

Rabbit

Positive Control

HL-60 cell lysate, THP-1 cell lysate, RAW264.7 cell lysate, PC-12 cell lysate, THP-1, RAW264.7, PC-12.

Conjugation

Unconjugated

Clonality

Monoclonal

Clone Number

PSH0-41

RRID

AB_3072460

APPLICATION DILUTION

  • WB

  • 1:1,000

  • IF-Cell

  • 1:100

  • FC

  • 1:500-1:1,000

PROPERTIES

Form

Liquid

Storage Condition

Shipped at 4℃. Store at +4℃ short term (1-2 weeks). It is recommended to aliquot into single-use upon delivery. Store at -20℃ long term.

Storage Buffer

PBS (pH7.4), 0.1% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.

Concentration

1ug/ul

Purification

Protein A affinity purified.

Molecular Weight

Predicted band size: 62.2 kDa

Isotype

IgG

TARGET

UNIPROT #

Q9H257

PROTEIN NAME

CARD9

SYNONYMS

CANDF2 antibody;CARD9 antibody;CARD9_HUMAN antibody;Caspase recruitment domain family member 9 antibody;Caspase recruitment domain-containing protein 9 antibody;hCARD9 antibody

SUBCELLULAR LOCATION

Cytoplasm..

FUNCTION

Caspase recruitment domain-containing protein 9 is an adaptor protein of the CARD-CC protein family, which in humans is encoded by the CARD9 gene. It mediates signals from pattern recognition receptors to activate pro-inflammatory and anti-inflammatory cytokines, regulating inflammation. Homozygous mutations in CARD9 are associated with defective innate immunity against yeasts, like Candida and dermatophytes. CARD9 is a member of the CARD protein family, which is defined by the presence of a characteristic caspase-associated recruitment domain (CARD). This protein was identified by its selective association with the CARD domain of BCL10, a positive regulator and NF-κB activation. It is thought to function as a molecular scaffold for the assembly of a BCL10 signaling complex that activates NF-κB. Several alternatively spliced transcript variants have been observed, but their full-length nature is not clearly defined.

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