Cardiac Troponin T Mouse Monoclonal Antibody [3-G6] (EM1701-39)

UNIPROT #

P45379

PROTEIN NAME

Cardiac Troponin T

SYNONYMS

Cardiac muscle troponin T antibody;Cardiomyopathy dilated 1D (autosomal dominant) antibody;Cardiomyopathy hypertrophic 2 antibody;CMD1D antibody;CMH2 antibody;CMPD2 antibody;cTnT antibody;LVNC6 antibody;MGC3889 antibody;OTTHUMP00000033864 antibody;OTTHUMP00000033865 antibody;OTTHUMP00000033866 antibody;OTTHUMP00000033867 antibody;OTTHUMP00000033870 antibody;OTTHUMP00000218095 antibody;RCM3 antibody;TNNT 2 antibody;TNNT2 antibody;TNNT2_HUMAN antibody;TnTc antibody;Troponin T cardiac muscle antibody;Troponin T type 2 (cardiac) antibody;Troponin T type 2 cardiac antibody;Troponin T, cardiac muscle antibody;Troponin T2 cardiac antibody

SEQUENCE SIMILARITIES

Belongs to the troponin T family.

TISSUE SPECIFICITY

Heart. The fetal heart shows a greater expression in the atrium than in the ventricle, while the adult heart shows a greater expression in the ventricle than in the atrium. Isoform 6 predominates in normal adult heart. Isoforms 1, 7 and 8 are expressed in fetal heart. Isoform 7 is also expressed in failing adult heart.

POST-TRANSLATIONAL MODIFICATION

Phosphorylation at Thr-213 by PRKCA induces significant reduction in myofilament calcium sensitivity and actomyosin ATPase activity.

SUBCELLULAR LOCATION

Cytoskeleton, Cytosol.

FUNCTION

Cardiac muscle troponin T (cTnT) is a protein that in humans is encoded by the TNNT2 gene. Cardiac TnT is the tropomyosin-binding subunit of the troponin complex, which is located on the thin filament of striated muscles and regulates muscle contraction in response to alterations in intracellular calcium ion concentration.The TMNT2 gene is located at 1q32 in the human chromosomal genome, encoding the cardiac muscle isoform of troponin T (cTnT). Human cTnT is an ~36-kDa protein consisting of 297 amino acids including the first methionine with an isoelectric point (pI) of 4.88. It is the tropomyosin- binding and thin filament anchoring subunit of the troponin complex in cardiac muscle cells. TNNT2 gene is expressed in vertebrate cardiac muscles and embryonic skeletal muscles.