Caspase-6 Recombinant Rabbit Monoclonal Antibody [SC56-09] (ET1610-24)

UNIPROT #

P55212

PROTEIN NAME

Caspase-6

SYNONYMS

Caspase6;Apoptotic protease Mch-2 antibody;Apoptotic protease MCH2 antibody;CASP-6 antibody;CASP6 antibody;CASP6_HUMAN antibody;Caspase 6 antibody;Caspase 6 apoptosis related cysteine protease antibody;Caspase 6, apoptosis related cysteine peptidase antibody;Caspase-6 subunit p11 antibody;Mch2 antibody;OTTHUMP00000162742 antibody;OTTHUMP00000162743 antibody

SEQUENCE SIMILARITIES

Belongs to the peptidase C14A family.

POST-TRANSLATIONAL MODIFICATION

Cleavages by caspase-3, caspase-8 or -10 generate the two active subunits.

SUBCELLULAR LOCATION

Cytoplasm, Nucleus.

FUNCTION

A unique family of cysteine proteases has been described that differs in sequence, structure and substrate specificity from any previously described protease family. This family, Ced-3/caspase-1, is comprised of caspase-1, caspase-2, caspase-3, caspase-4, caspase-6, caspase-7 (also designated Mch3, ICE-LAP3 or CMH-1), caspase-9 and caspase-10. Ced-3/ caspase-1 family members function as key components of the apoptotic machinery and act to destroy specific target proteins which are critical to cellular longevity. Poly(ADP-ribose)polymerase plays an integral role in surveying for DNA mutations and double strand breaks. Caspase-3, caspase-7 and caspase-9, but not caspase-1, have been shown to cleave the nuclear protein PARP into an apoptotic fragment. caspase-6, but not caspase-3, has been shown to cleave the nuclear lamins, which are critical to maintaining the integrity of the nuclear envelope and cellular morphology. Caspase-10 has been shown to activate caspase-3 and caspase-7 in response to apoptotic stimuli.