CCL2 Rabbit Polyclonal Antibody (HA500267)
Catalog# HA500267
Rabbit Polyclonal to CCL2
-
WB
-
FC
-
Mouse
-
Human
Specifications
Product Type
Rabbit polyclonal primary
Product Name
CCL2 Rabbit Polyclonal Antibody (HA500267)
Immunogen
Synthetic peptide within human ccl2 aa 30-70 / 99.
Host
Rabbit
Positive Control
Mouse testis tissue lysates.
Conjugation
Unconjugated
Clonality
Polyclonal
RRID
APPLICATION DILUTION
-
WB
-
1:500-1:1,000
-
FC
-
1:500-1:1,000
PROPERTIES
Form
Liquid
Storage Condition
Store at +4C after thawing. Aliquot store at -20C. Avoid repeated freeze / thaw cycles.
Storage Buffer
1*TBS (pH7.4), 0.2% BSA, 50% Glycerol. Preservative: 0.05% Sodium Azide.
Concentration
1ug/ul
Purification
Immunogen affinity purified.
Molecular Weight
Predicted band size: 11 kDa
Isotype
IgG
TARGET
UNIPROT #
PROTEIN NAME
CCL2
SYNONYMS
C-C motif chemokine 2 antibody;CCL2 antibody;CCL2_HUMAN antibody;Chemokine (C C motif) ligand 2 antibody;GDCF 2 antibody;GDCF-2 antibody;GDCF2 antibody;HC11 antibody;HSMCR30 antibody;JE antibody;MCAF antibody;MCP 1 antibody;MCP-1 antibody;MCP1 antibody;MGC9434 antibody;Monocyte chemoattractant protein 1 antibody;Monocyte chemotactic and activating factor antibody;Monocyte chemotactic protein 1 antibody;Monocyte secretory protein JE antibody;SCYA2 antibody;Small inducible cytokine A2 (monocyte chemotactic protein 1, homologous to mouse Sig je) antibody;Small inducible cytokine A2 antibody;Small inducible cytokine subfamily A (Cys Cys), member 2 antibody;Small-inducible cytokine A2 antibody;SMC CF antibody;SMC-CF antibody;SMCCF antibody
SUBCELLULAR LOCATION
Secreted.
FUNCTION
CCL2 exhibits a chemotactic activity for monocytes and basophils. However, it does not attract neutrophils or eosinophils. After deletion of the N-terminal residue, CCL2 loses its attractivity for basophils and becomes a chemoattractant of eosinophils. Basophils and mast cells that are treated with CCL2 release their granules to the intercellular space. This effect can be also potentiated by a pre-treatment with IL-3 or even by other cytokines. CCL2 augments monocyte anti-tumor activity and it is essential for formation of granulomas. CCL2 protein become a CCR2 antagonist when it is cleaved by metalloproteinase MMP-12.
CITATIONS
-
Wu, Q., Xu, R., Zhang, K., Sun, R., Yang, M., Li, K., Liu, H., Xue, Y., Xu, H., & Guo, Y.
Characterization of early myocardial inflammation in ischemia-reperfusion injury
-
WB
-
Mouse
-
Citation
-
-
Linxi Lv , Hui Jiang , Dianze Song ,et al
Sirt3 improves monosodium urate crystal-induced inflammation by suppressing Acod1 expression
-
WB
-
Mouse
-
Citation
-
Popup
Use this popup to embed a mailing list sign up form. Alternatively use it as a simple call to action with a link to a product or a page.
Age verification
By clicking enter you are verifying that you are old enough to consume alcohol.