CCR2 Recombinant Rabbit Monoclonal Antibody [SN707] (ET1611-65)

UNIPROT #

P41597

PROTEIN NAME

CCR2

SYNONYMS

C C chemokine receptor type 2 antibody;C C CKR 2 antibody;C-C chemokine receptor type 2 antibody;C-C CKR-2 antibody;CC chemokine receptor type 2 antibody;CC CKR 2 antibody;CC-CKR-2 antibody;CCCKR2 antibody;CCR 2 antibody;CCR-2 antibody;CCR1L antibody;CCR2 antibody;CCR2_HUMAN antibody;CCR2A antibody;CCR2B antibody;CCR5L antibody;CD192 antibody;CD192 antigen antibody;Chemokine C C motif receptor 2 antibody;Chemokine CC Motif Receptor 2 antibody;CKR 2 antibody;CKR2 antibody;CKR2A antibody;CKR2B antibody;CMKBR2 antibody;MCP 1 R antibody;MCP-1-R antibody;MCP1 RECEPTOR antibody;MCP1R antibody;Monocyte chemoattractant protein 1 receptor antibody;Monocyte Chemotactic Protein 1 Receptor antibody;Monocyte Chemotactic Protein 1 Receptor antibody

SEQUENCE SIMILARITIES

Belongs to the G-protein coupled receptor 1 family.

TISSUE SPECIFICITY

Expressed by monocytes and IL2-activated NK cells.

POST-TRANSLATIONAL MODIFICATION

N-glycosylated.; Sulfation increases the affinity for both monomeric and dimeric CCL2 with stronger binding to the monomeric form. Binding of sulfated CCR2 to CCL2 promotes conversion of CCL2 from dimer to monomer.

SUBCELLULAR LOCATION

Cell membrane.

FUNCTION

Key functional receptor for CCL2 but can also bind CCL7 and CCL12. Its binding with CCL2 on monocytes and macrophages mediates chemotaxis and migration induction through the activation of the PI3K cascade, the small G protein Rac and lamellipodium protrusion (Probable). Also acts as a receptor for the beta-defensin DEFB106A/DEFB106B. Regulates the expression of T-cell inflammatory cytokines and T-cell differentiation, promoting the differentiation of T-cells into T-helper 17 cells (Th17) during inflammation. Facilitates the export of mature thymocytes by enhancing directional movement of thymocytes to sphingosine-1-phosphate stimulation and up-regulation of S1P1R expression; signals through the JAK-STAT pathway to regulate FOXO1 activity leading to an increased expression of S1P1R. Plays an important role in mediating peripheral nerve injury-induced neuropathic pain. Increases NMDA-mediated synaptic transmission in both dopamine D1 and D2 receptor-containing neurons, which may be caused by MAPK/ERK-dependent phosphorylation of GRIN2B/NMDAR2B. Mediates the recruitment of macrophages and monocytes to the injury site following brain injury.