CD10 Mouse Monoclonal Antibody [A1G4] (EM1901-25)

UNIPROT #

P08473

PROTEIN NAME

CD10

SYNONYMS

Atriopeptidase antibody;CALLA antibody;CD10 antibody;CD10 antigen antibody;Common acute lymphocytic leukemia antigen antibody;DKFZp686O16152 antibody;EC 3.4.24.11 antibody;Enkephalinase antibody;EPN antibody;Membrane metallo endopeptidase (neutral endopeptidase, enkephalinase) antibody;Membrane metallo endopeptidase (neutral endopeptidase, enkephalinase, CALLA, CD10) antibody;Membrane metallo endopeptidase antibody;Membrane metallo endopeptidase variant 1 antibody;Membrane metallo endopeptidase variant 2 antibody;Membrane metalloendopeptidase antibody;Membrane metalloendopeptidase neutral endopeptidase enkephalinase antibody;Membrane metalloendopeptidase neutral endopeptidase enkephalinase CALLA CD10 antibody;Membrane metalloendopeptidase variant 1 antibody;Membrane metalloendopeptidase variant 2 antibody;MGC126681 antibody;MGC126707 antibody;MME antibody;NEP antibody;NEP_HUMAN antibody;Neprilysin antibody;neprilysin-390 antibody;neprilysin-411 antibody;Neutral endopeptidase 24.11 antibody;Neutral endopeptidase antibody;Neutral endopeptidase, membrane-associated antibody;SFE antibody;Skin fibroblast elastase antibody

SEQUENCE SIMILARITIES

Belongs to the peptidase M13 family.

POST-TRANSLATIONAL MODIFICATION

Myristoylation is a determinant of membrane targeting.; Glycosylation at Asn-628 is necessary both for surface expression and neutral endopeptidase activity.

SUBCELLULAR LOCATION

Cell membrane.

FUNCTION

This gene encodes a common acute lymphocytic leukemia antigen that is an important cell surface marker in the diagnosis of human acute lymphocytic leukemia (ALL). This protein is present on leukemic cells of pre-B phenotype, which represent 85% of cases of ALL. This protein is not restricted to leukemic cells, however, and is found on a variety of normal tissues. It is a glycoprotein that is particularly abundant in kidney, where it is present on the brush border of proximal tubules and on glomerular epithelium. The protein is a neutral endopeptidase that cleaves peptides at the amino side of hydrophobic residues and inactivates several peptide hormones including glucagon, enkephalins, substance P, neurotensin, oxytocin, and bradykinin. This gene, which encodes a 100-kD type II transmembrane glycoprotein, exists in a single copy of greater than 45 kb. The 5' untranslated region of this gene is alternatively spliced, resulting in four separate mRNA transcripts. The coding region is not affected by alternative splicing.