CD147 Rabbit Polyclonal Antibody (1003-10)

UNIPROT #

P18572

PROTEIN NAME

CD147

SYNONYMS

5A11 antigen antibody;5F7 antibody;BASI_HUMAN antibody;Basigin (Ok blood group) antibody;Basigin antibody;Blood brain barrier HT7 antigen antibody;Bsg antibody;CD 147 antibody;CD147 antibody;CD147 antigen antibody;Collagenase stimulatory factor antibody;EMMPRIN antibody;Extracellular matrix metalloproteinase inducer antibody;Leukocyte activation antigen M6 antibody;M 6 antibody;M6 antibody;M6 leukocyte activation antigen antibody;Neurothelin antibody;OK antibody;OK blood group antibody;OK blood group antigen antibody;TCSF antibody;Tumor cell derived collagenase stimulatory factor antibody;Tumor cell-derived collagenase stimulatory factor antibody

TISSUE SPECIFICITY

Isoform 1 is specifically expressed in retina. Isoform 2 is widely expressed, including adult organs, embryos and EC cells. Expressed in spermatozoa.

DEVELOPMENTAL STAGE

In developing eye expressed at embryonic days 12 dpc, 15 dpc and 18 dpc, and at postnatal days P1, P7, P14, and P21. Expression progressed from a more generalized distribution throughout the undifferentiated neural retina to specific staining of retina-pigmented epithilia, the MCs, photoreceptor cells and the ciliary apparatus. Expression is highest at P21. Isoform 1 and isoform 2 are expressed at equivalent levels at P7, isoform 1 is more abundant at P14, P21 and P28. In uterus during the peri-implantation period strongly expressed in luminal and glandular epithelium on day 1 of pregnancy and gradually decreased to a basal level from day 2-4 of pregnancy. Expression in the sub-luminal stroma was first detected on day 3 of pregnancy and increased on day 4 of pregnancy. On day 5 of pregnancy, the expression of basigin protein and mRNA was only detected in the implanting embryos, and the luminal epithelium and sub-luminal stroma surrounding the embryos. In ovary during sexual maturation expressed in the granulosa cells of preantral follicles at days 20 and 25 after birth. Expressed during corpus luteum formation.

POST-TRANSLATIONAL MODIFICATION

N-glycosylated. During spermatogenesis, probably deglycosylated during epididymal transit.

SUBCELLULAR LOCATION

Cell membrane, Photoreceptor inner segment, Cell projection, cilium, photoreceptor outer segment; Endoplasmic reticulum membrane, Basolateral cell membrane.

FUNCTION

CD147 (Basigin) is a member of the immunoglobulin superfamily, with a structure related to the putative primordial form of the family. CD147 is a widely expressed membrane glycoprotein that plays pivotal roles in spermatogenesis, embryo implantation, neural network formation and tumor progression. It stimulates adjacent fibroblasts to produce matrix metalloproteinases (MMPS) and may target monocarboxylate transporters SLC16A1, SLC16A3 and SLC16A8 to plasma membranes of retinal pigment epithelium and neural retina. In vitro, CD147 promotes outgrowth of astrocytic processes.