CD163 Rabbit Polyclonal Antibody (ER2001-15)

UNIPROT #

Q86VB7

PROTEIN NAME

CD163

SYNONYMS

C163A_HUMAN antibody;CD 163 antibody;CD163 antibody;CD163 antigen antibody;CD163 molecule antibody;Hemoglobin scavenger receptor antibody;M130 antibody;M130 antigen precursor antibody;Macrophage associated antigen antibody;MM130 antibody;OTTHUMP00000238617 antibody;OTTHUMP00000238618 antibody;OTTHUMP00000238619 antibody;OTTHUMP00000238620 antibody;SCARI1 antibody;Scavenger receptor cysteine rich type 1 protein M130 antibody;sCD163 antibody;Soluble CD163 antibody

SUBCELLULAR LOCATION

Secreted, Cell membrane.

FUNCTION

The protein encoded by this gene is a member of the scavenger receptor cysteine-rich (SRCR) superfamily, and is exclusively expressed in monocytes and macrophages. It functions as an acute phase-regulated receptor involved in the clearance and endocytosis of hemoglobin/haptoglobin complexes by macrophages, and may thereby protect tissues from free hemoglobin-mediated oxidative damage. This protein may also function as an innate immune sensor for bacteria and inducer of local inflammation. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.