CD18 Recombinant Rabbit Monoclonal Antibody [JM71-31] (ET1703-94)

UNIPROT #

P05107

PROTEIN NAME

CD18

SYNONYMS

95 subunit beta antibody;Beta 2 (antigen CD18 (p95) antibody;CD 18 antibody;CD18 antibody;Cell surface adhesion glycoprotein LFA 1/CR3/P150,959 beta subunit precursor) antibody;Cell surface adhesion glycoproteins LFA 1/CR3/p150,95 subunit beta antibody;Cell surface adhesion glycoproteins LFA-1/CR3/p150 antibody;Complement component 3 receptor 3 and 4 subunit antibody;Complement receptor C3 beta subunit antibody;Complement receptor C3 subunit beta antibody;Integrin beta 2 antibody;Integrin beta chain beta 2 antibody;Integrin beta-2 (ITGB2) antibody;Integrin beta-2 antibody;Integrin, beta 2 (complement component 3 receptor 3 and 4 subunit) antibody;ITB2_HUMAN antibody;ITGB2 antibody;LAD antibody;LCAMB antibody;Leukocyte associated antigens CD18/11A, CD18/11B, CD18/11C antibody;Leukocyte cell adhesion molecule CD18 antibody;LFA 1 antibody;LFA1 antibody;Lymphocyte function associated antigen 1 (LFA1) antibody;Lymphocyte function associated antigen 1 antibody;MAC 1 antibody;MAC1 antibody;Macrophage antigen 1 (mac1) beta antibody;MF17 antibody;MFI7 antibody;OTTHUMP00000115278 antibody;OTTHUMP00000115279 antibody;OTTHUMP00000115280 antibody;OTTHUMP00000115281 antibody;OTTHUMP00000115282 antibody

SEQUENCE SIMILARITIES

Belongs to the integrin beta chain family.

TISSUE SPECIFICITY

Leukocytes. Expressed in neutrophils (at protein level).

POST-TRANSLATIONAL MODIFICATION

Both Ser-745 and Ser-756 become phosphorylated when T-cells are exposed to phorbol esters. Phosphorylation on Thr-758 (but not on Ser-756) allows interaction with 14-3-3 proteins.

SUBCELLULAR LOCATION

Membrane.

FUNCTION

Integrins are heterodimers composed of noncovalently associated transmembrane a and b subunits. The 16 a and 8 b subunits heterodimerize to produce more than 20 different receptors. Most integrin receptors bind ligands that are components of the extracellular matrix, including Fibronectin, Collagen and Vitronectin. Certain integrins can also bind to soluble ligands such as Fibrinogen, or to counterreceptors on adjacent cells such as the intracellular adhesion molecules (ICAMs), leading to aggregation of cells. Ligands serve to cross-link or cluster integrins by binding to adjacent integrin receptors; both receptor clustering and ligand occupancy are necessary for the activation of integrin-mediated responses. In addition to mediating cell adhesion and cytoskeletal organization, integrins function as signaling receptors. Signals transduced by integrins play a role in many biological processes, including cell growth, differentiation, migration and apoptosis.