CD19 Rabbit Polyclonal Antibody (R1107-7)

UNIPROT #

P15391

PROTEIN NAME

CD19

SYNONYMS

antibody;deficiency due to defect in CD19, included antibody;AW495831 antibody;B lymphocyte antigen CD19 antibody;B lymphocyte surface antigen B4 antibody;B-lymphocyte antigen CD19 antibody;B-lymphocyte surface antigen B4 antibody;B4 antibody;CD19 antibody;CD19 antigen antibody;CD19 molecule antibody;Cd19 protein antibody;CD19_HUMAN antibody;CVID3 antibody;Differentiation antigen CD19 antibody;Leu 12 antibody;Leu-12 antibody;Leu12 antibody;MGC109570 antibody;MGC12802 antibody;T-cell surface antigen Leu-12 antibody

TISSUE SPECIFICITY

Detected on marginal zone and germinal center B cells in lymph nodes. Detected on blood B cells (at protein level).

POST-TRANSLATIONAL MODIFICATION

Phosphorylated on tyrosine following B-cell activation. Phosphorylated on tyrosine residues by LYN. Tyrosine residues are phosphorylated sequentially after activation of the B cell receptor. Phosphorylation of Tyr-531 is extremely rapid, followed by phosphorylation at Tyr-409. In contrast, phosphorylation of Tyr-500 appears more slowly and is more transient, returning rapidly to basal levels (By similarity).

SUBCELLULAR LOCATION

Cell membrane

FUNCTION

B-lymphocyte antigen CD19 also known as CD19 (Cluster of Differentiation 19), is a 95 kDa type-I transmembrane glycoprotein which is restricted to B cell antigen. On the B cell surface, CD19 associates with CD21, CD81 and Leu-13 to exert its function. CD19 is also found on the follicular dendritic cells and the early cells of myelomonocytic lineage but not on normal T cells, NK cells, monocytes, granulocytes, erythrocytes and platelets.