CD1a Recombinant Rabbit Monoclonal Antibody [JM21-33] (ET1705-17)

UNIPROT #

P06126

PROTEIN NAME

CD1a

SYNONYMS

CD 1a antibody;CD1 antibody;CD1a antibody;CD1A Antigen antibody;CD1A antigen, a polypeptide antibody;CD1a molecule antibody;CD1A_HUMAN antibody;cluster of differentiation 1 A antibody;cortical thymocyte antigen CD1A antibody;differentiation antigen CD1 alpha 3 antibody;epidermal dendritic cell marker CD1a antibody;FCB 6 antibody;FCB6 antibody;HTA 1 antibody;HTA1 antibody;hTa1 thymocyte antigen antibody;OTTHUMP00000018907 antibody;R 4 antibody;R4 antibody;T 6 antibody;T-cell surface antigen T6/Leu-6 antibody;T-cell surface glycoprotein CD1a antibody;T6 antibody

TISSUE SPECIFICITY

Expressed on cortical thymocytes, epidermal Langerhans cells, dendritic cells, on certain T-cell leukemias, and in various other tissues.

SUBCELLULAR LOCATION

Cell membrane. Endosome membrane.

FUNCTION

CD1a (Cluster of Differentiation 1a) is a human protein encoded by the CD1A gene. This gene encodes a member of the CD1 family of transmembrane glycoproteins, which are structurally related to the major histocompatibility complex (MHC) proteins and form heterodimers with beta-2-microglobulin. The CD1 proteins mediate the presentation of primarily lipid and glycolipid antigens of self or microbial origin to T cells. The human genome contains five CD1 family genes organized in a cluster on chromosome 1. The CD1 family members are thought to differ in their cellular localization and specificity for particular lipid ligands. The protein encoded by this gene localizes to the plasma membrane and to recycling vesicles of the early endocytic system. Alternatively spliced transcript variants have been observed, but their biological validity has not been determined. Transcript levels of the CD1A gene are upregulated in the lung parenchyma of smokers.