CD24 Rabbit Polyclonal Antibody (0804-3)
Catalog# 0804-3
Rabbit Polyclonal to CD24
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WB
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IHC-P
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FC
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Mouse
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Human
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Rat
Specifications
Product Type
Rabbit polyclonal primary
Product Name
CD24 Rabbit Polyclonal Antibody (0804-3)
Immunogen
Synthetic peptide within mouse cd24 aa 27-76 / 76.
Host
Rabbit
Positive Control
Mouse brain tissue lysates, mouse thymus tissue lysates, mouse spleen tissue, N2A.
Conjugation
Unconjugated
Clonality
Polyclonal
RRID
APPLICATION DILUTION
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WB
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1:500-1:2,000
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IHC-P
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1:50-1:200
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FC
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1:50-1:100
PROPERTIES
Form
Liquid
Storage Condition
Store at +4C after thawing. Aliquot store at -20C or -80C. Avoid repeated freeze / thaw cycles.
Storage Buffer
1*PBS (pH7.4), 0.2% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Concentration
1ug/ul
Purification
Immunogen affinity purified.
Molecular Weight
Predicted band size: 8 kDa
Isotype
IgG
TARGET
UNIPROT #
PROTEIN NAME
CD24
SYNONYMS
CD 24 antibody;CD24 antibody;CD24 antigen (small cell lung carcinoma cluster 4 antigen) antibody;CD24 antigen antibody;CD24 molecule antibody;CD24_HUMAN antibody;CD24A antibody;FLJ22950 antibody;FLJ43543 antibody;GPI linked surface mucin antibody;Heat stable antigen antibody;HSA antibody;MGC75043 antibody;Nectadrin antibody;Signal transducer CD24 antibody;Small cell lung carcinoma cluster 4 antigen antibody
SEQUENCE SIMILARITIES
Belongs to the CD24 family.
TISSUE SPECIFICITY
In lymphoid, myeloid, and erythroid cells.
POST-TRANSLATIONAL MODIFICATION
The identity of the N- and O-linked polysaccharides are not reported in PubMed:1530634. The O-linked polysaccharides on Ser-30, Ser-41, Ser-43, and Thr-51 are probably the mucin type linked to GalNAc.
SUBCELLULAR LOCATION
Cell membrane.
FUNCTION
The CD24 antigen is a small heavily glycosylated, glycosylphosphatidylinositol (GPI) linked cell surface protein. It consists of a small protein core comprising 27 amino acids, which is extensively glycosylated and is bound to the membrane via a phosphatidylinositol anchor. The CD24 antigen is physiologically expressed in developing or regenerating tissue, as well as in granulocytes, keratinocytes and renal tubular epithelium. It modulates B-cell activation responses. Signaling could be triggered by the binding of a lectin-like ligand to the CD24 carbohydrates, and transduced by the release of second messengers derived from the GPI-anchor.
CITATIONS
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Shu, Y., Xu, Q., Xu, Y., Tao, Q., Shao, M., Cao, X., Chen, Y., Wu, Z., Chen, M., Zhou, Y., Zhou, P., Shi, Y., & Bu, H.
Loss of Numb promotes hepatic progenitor expansion and intrahepatic cholangiocarcinoma by enhancing Notch signaling
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WB
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Mouse
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Citation
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Zhou Xiaofeng,et al
The Hippo-YAP signaling pathway drives CD24-mediated immune evasion in esophageal squamous cell carcinoma via macrophage phagocytosis
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WB
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IHC
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Human
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Citation
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