CD33 Recombinant Rabbit Monoclonal Antibody [PSH02-50] (HA721826)

UNIPROT #

P20138

PROTEIN NAME

CD33

SYNONYMS

CD 33 antibody;CD33 antibody;CD33 antigen (gp67) antibody;CD33 antigen antibody;CD33 molecule antibody;CD33_HUMAN antibody;FLJ00391 antibody;gp67 antibody;My9 antibody;Myeloid cell surface antigen CD33 antibody;Myeloid cell surface antigen CD33 precursor antibody;Myeloid differentiation antigen CD33 antibody;p67 antibody;Sialic acid binding Ig like lectin 3 antibody;Sialic acid binding immunoglobulin like lectin 3 antibody;Sialic acid-binding Ig-like lectin 3 antibody;SIGLEC 3 antibody;Siglec-3 antibody;SIGLEC3 antibody

SUBCELLULAR LOCATION

Cell membrane; Peroxisome.

FUNCTION

CD33 or Siglec-3 (sialic acid binding Ig-like lectin 3, SIGLEC3, SIGLEC-3, gp67, p67) is a transmembrane receptor expressed on cells of myeloid lineage. It is usually considered myeloid-specific, but it can also be found on some lymphoid cells. It binds sialic acids, therefore is a member of the SIGLEC family of lectins. CD33 can be stimulated by any molecule with sialic acid residues such as glycoproteins or glycolipids. Upon binding, the immunoreceptor tyrosine-based inhibition motif (ITIM) of CD33, present on the cytosolic portion of the protein, is phosphorylated and acts as a docking site for Src homology 2 (SH2) domain-containing proteins like SHP phosphatases. This results in a cascade that inhibits phagocytosis in the cell.