CD41 Recombinant Rabbit Monoclonal Antibody [JM11-19] (ET1703-37)

UNIPROT #

P08514

PROTEIN NAME

CD41

SYNONYMS

antigen CD41 antibody;BDPLT16 antibody;BDPLT2 antibody;CD41 antibody;CD41B antibody;form 2 antibody;GP2B antibody;GPalpha IIb antibody;GPIIb antibody;GT antibody;GTA antibody;HPA3 antibody;Integrin alpha 2b antibody;Integrin alpha IIb antibody;Integrin alpha-IIb light chain antibody;Integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41) antibody;ITA2B_HUMAN antibody;Itga2b antibody;ITGAB antibody;platelet fibrinogen receptor, alpha subunit antibody;platelet glycoprotein IIb of IIb/IIIa complex antibody;Platelet membrane glycoprotein IIb antibody;platelet specific antigen BAK antibody;PPP1R93 antibody

SEQUENCE SIMILARITIES

Belongs to the integrin alpha chain family.

TISSUE SPECIFICITY

Isoform 1 and isoform 2 are expressed in platelets and megakaryocytes, but not in reticulocytes. Not detected in Jurkat, nor in U937 cell lines. Isoform 3 is expressed in prostate adenocarcinoma, as well as in several erythroleukemia, prostate adenocarcinoma and melanoma cell lines, including PC-3, DU-145, HEL, WM983A, WM983B and WM35. Not detected in platelets, nor in normal prostate (at protein level).

SUBCELLULAR LOCATION

Membrane.

FUNCTION

Integrins are heterodimers composed of noncovalently associated transmembrane α and β subunits. The 16 α and 8 β subunits heterodimerize to produce more than 20 different receptors. Most integrin receptors bind ligands that are components of the extracellular matrix, including Fibronectin, collagen and Vitronectin. Certain integrins can also bind to soluble ligands such as Fibrinogen, or to counterreceptors on adjacent cells such as the intracellular adhesion molecules (ICAMs), leading to aggregation of cells. Ligands serve to cross-link or cluster integrins by binding to adjacent integrin receptors; both receptor clustering and ligand occupancy are necessary for the activation of integrin-mediated responses. In addition to mediating cell adhesion and cytoskeletal organization, integrins function as signaling receptors. Signals transduced by integrins play a role in many biological processes, including cell growth, differentiation, migration and apoptosis.