CD45 Rabbit Polyclonal Antibody (ER1902-02)

UNIPROT #

P08575

PROTEIN NAME

CD45

SYNONYMS

B220 antibody;CD 45 antibody;CD45 antibody;CD45 antigen antibody;CD45R antibody;GP180 antibody;L-CA antibody;LCA antibody;Leukocyte common antigen antibody;loc antibody;Ly-5 antibody;LY5 antibody;Ly5, homolog of antibody;Lyt-4 antibody;OTTHUMP00000033813 antibody;OTTHUMP00000033816 antibody;OTTHUMP00000033817 antibody;OTTHUMP00000038574 antibody;Protein tyrosine phosphatase receptor type c polypeptide antibody;Protein tyrosine phosphatase, receptor type C antibody;protein tyrosine phosphatase, receptor type, C antibody;Protein tyrosine phosphatase, receptor type, c polypeptide antibody;Ptprc antibody;PTPRC_HUMAN antibody;Receptor-type tyrosine-protein phosphatase C antibody;T200 antibody;T200 glycoprotein antibody;T200 leukocyte common antigen antibody

SEQUENCE SIMILARITIES

Belongs to the protein-tyrosine phosphatase family. Receptor class 1/6 subfamily.

TISSUE SPECIFICITY

Isoform 1: Detected in thymocytes. Isoform 2: Detected in thymocytes. Isoform 3: Detected in thymocytes. Isoform 4: Not detected in thymocytes. Isoform 5: Detected in thymocytes. Isoform 6: Not detected in thymocytes. Isoform 7: Detected in thymocytes. Isoform 8: Not detected in thymocytes.

DEVELOPMENTAL STAGE

Isoform 1: During T-cell development, expressed at the CD3-CD4-CD8- and CD3+CD4+CD8- stages but barely detectable at the CD3-CD4+CD8+ stage. Isoform 2: During T-cell development, expressed at low levels at the CD3-CD4-CD8- and CD3-CD4+CD8- stages but up-regulated at the CD3+CD4+CD8+ and CD3+CD4+CD8- stages. Isoform 3: During T-cell development, expressed at the CD3-CD4-CD8- and CD3+CD4+CD8- stages but barely detectable at the CD3-CD4+CD8+ stage. Isoform 5: During T-cell development, expressed at the CD3-CD4-CD8- and CD3+CD4+CD8- stages but barely detectable at the CD3-CD4+CD8+ stage. Isoform 7: Consistently expressed at high levels at all stages of T-cell development.

POST-TRANSLATIONAL MODIFICATION

Heavily N- and O-glycosylated.

SUBCELLULAR LOCATION

Cell membrane, membrane raft.

FUNCTION

The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitosis, and oncogenic transformation. This PTP contains an extracellular domain, a single transmembrane segment and two tandem intracytoplasmic catalytic domains, and thus is classified as a receptor type PTP. This PTP has been shown to be an essential regulator of T- and B-cell antigen receptor signaling. It functions through either direct interaction with components of the antigen receptor complexes, or by activating various Src family kinases required for the antigen receptor signaling. This PTP also suppresses JAK kinases, and thus functions as a regulator of cytokine receptor signaling. Alternatively spliced transcripts variants of this gene, which encode distinct isoforms, have been reported.