CD46 Recombinant Rabbit Monoclonal Antibody [JB25-49] (ET7107-94)

UNIPROT #

P15529

PROTEIN NAME

CD46

SYNONYMS

AHUS2 antibody;Antigen defined by monoclonal antibody TRA 2 10 antibody;Antigen identified by monoclonal antibody TRA 2 10 antibody;CD46 antibody;CD46 antigen antibody;CD46 antigen complement regulatory protein antibody;CD46 molecule antibody;CD46 molecule complement regulatory protein antibody;Complement membrane cofactor protein antibody;MCP antibody;MCP_HUMAN antibody;Measles virus receptor antibody;membrane cofactor protein (CD46, trophoblast-lymphocyte cross-reactive antigen) antibody;Membrane cofactor protein antibody;MGC26544 antibody;MIC10 antibody;TLX antibody;TRA2.10 antibody;Trophoblast leucocyte common antigen antibody;Trophoblast leukocyte common antigen antibody;Trophoblast lymphocyte cross reactive antigen antibody

TISSUE SPECIFICITY

Expressed by all cells except erythrocytes.

POST-TRANSLATIONAL MODIFICATION

N-glycosylated on Asn-83; Asn-114 and Asn-273 in most tissues, but probably less N-glycosylated in testis. N-glycosylation on Asn-114 and Asn-273 is required for cytoprotective function. N-glycosylation on Asn-114 is required for Measles virus binding. N-glycosylation on Asn-273 is required for Neisseria binding. N-glycosylation is not required for human adenovirus binding.; Extensively O-glycosylated in the Ser/Thr-rich domain. O-glycosylation is required for Neisseria binding but not for Measles virus or human adenovirus binding.; In epithelial cells, isoforms B/D/F/H/J/L/3 are phosphorylated by YES1 in response to infection by Neisseria gonorrhoeae; which promotes infectivity. In T-cells, these isoforms may be phosphorylated by LCK.

SUBCELLULAR LOCATION

Acrosome inner membrane.

FUNCTION

CD46, also called membrane cofactor protein (MCP), is a transmembrane glycoprotein that exists as a non-disulfide-linked dimer. CD46 regulates the complement cascade by inhibiting C3b and C4b deposited on self tissue. CD46 is a cofactor that binds to C3b and C4b, allowing their degradation by a plasma serine protease called factor I. This function resides in the complement control protein repeats (CCPs), with CCP1-4 essential for regulation. CD46 is widely distributed on thymocytes, T cells, B cells, monocytes, granulocytes, NK cells, platelets, endothelial cells, epithelial cells, fibroblasts, placenta and sperm, but not on erythrocytes. It is the major high affinity receptor for measles virus and human herpes virus. Mouse cells ubiquitously express CRRY, which is a functional ortholog of human decay-accelerating factor (DAF; CD55) and membrane cofactor protein (MCP; CD46).