CD55 Rabbit Polyclonal Antibody (ER1802-46)

UNIPROT #

P08174

PROTEIN NAME

CD55

SYNONYMS

CD 55 antibody;CD55 antibody;CD55 antigen antibody;CD55 Cromer blood group system antibody;CD55 molecule (Cromer blood group) antibody;CD55 molecule antibody;CD55 molecule, decay accelerating factor for complement (Cromer blood group) antibody;Cd55a antibody;Complement decay accelerating factor antibody;Complement decay-accelerating factor antibody;Complement decay-accelerating factor, GPI-anchored antibody;CR antibody;CROM antibody;Cromer Blood Group antigen antibody;Cromer blood group system antibody;DAF antibody;Daf-GPI antibody;DAF_HUMAN antibody;Daf1 antibody;Dcay accelerating factor for complement (CD55, Cromer blood group system) antibody;Decay accelarating factor 1, isoform CRA_a antibody;Decay accelerating factor (GPI-form) antibody;Decay Accelerating Factor for Complement antibody;Decay accelerating factor GPI-form antibody;Decay accelerating factor soluble-form antibody;GPI-DAF antibody;TC antibody

SEQUENCE SIMILARITIES

Belongs to the receptors of complement activation (RCA) family.

TISSUE SPECIFICITY

Expressed on the plasma membranes of all cell types that are in intimate contact with plasma complement proteins. It is also found on the surfaces of epithelial cells lining extracellular compartments, and variants of the molecule are present in body fluids and in extracellular matrix.

POST-TRANSLATIONAL MODIFICATION

The Ser/Thr-rich domain is heavily O-glycosylated.

SUBCELLULAR LOCATION

Cell membrane. Secreted.

FUNCTION

CD55, also called decay accelerating factor (DAF), is a GPI-anchored single chain glycoprotein. CD55 may play a role in protecting cells from complement-mediated lysis by preventing the amplification steps of the complement cascade. CD55 functions to prevent the assembly of C3 convertase or to accelerate the disassembly of preformed convertase, which blocks formation of the membrane attack complex. CD55 is expressed on cells in contact with serum, including hematopoietic and many non-hematopoietic cells.