CD74 Recombinant Rabbit Monoclonal Antibody [JF40-10] (ET1702-51)

UNIPROT #

P04233

PROTEIN NAME

CD74

SYNONYMS

CD 74 antibody;CD74 antibody;CD74 antigen (invariant polypeptide of major histocompatibility complex, class II antigen-associated) antibody;CD74 antigen antibody;CD74 molecule antibody;CD74 molecule, major histocompatibility complex, class II invariant chain antibody;CLIP antibody;DHLAG antibody;Gamma chain of class II antigens antibody;HG2A_HUMAN antibody;HLA class II histocompatibility antigen gamma chain antibody;HLA DR antigens associated invariant chain antibody;HLA DR gamma antibody;HLA-DR antigens-associated invariant chain antibody;HLA-DR-gamma antibody;HLADG antibody;HLADR antigens associated invariant chain antibody;Ia antigen associated invariant chain antibody;Ia antigen-associated invariant chain antibody;Ia associated invariant chain antibody;Ia gamma antibody;Ii antibody;Invariant polypeptide of major histocompatibility complex class II antigen associated antibody;la-gamma antibody;Major histocompatibility complex class II invariant chain antibody;MHC HLA DR gamma chain antibody;MHC HLA-DR gamma chain antibody;p33 antibody;p35 antibody;Protein 41 antibody

POST-TRANSLATIONAL MODIFICATION

N- and O-glycosylated. O-glycosylated with core 1 or possibly core 8 glycans.

SUBCELLULAR LOCATION

Endoplasmic reticulum membrane, trans-Golgi network, cell membrane, lysosome, endosome.

FUNCTION

The human histocompatibility leukocyte antigen (HLA) class II-associated invariant chain is composed of at least four polypeptides. One of these polypeptide chains is expressed as a membrane-bound subunit and has been designated CD74. The loading of peptide onto the class II MHC protein (MHC II) appears to be regulated by CD74, which associates with MHC II during its migration to the endosomal compartment, where class II binds pep-tide. CD74 is expressed by cells of both T lymphocyte and B lymphocyte lineages. In fact, CD74 is broadly expressed in normal B lymphocytes, regardless of their histocompatibility leukocyte antigen (HLA) phenotype, while a subset of peripheral T lymphocytes that are MHC II negative do not express CD74.