CD8 alpha Rabbit Polyclonal Antibody (ER2001-19)

UNIPROT #

P01732

PROTEIN NAME

CD8 alpha

SYNONYMS

CD8 antibody;CD8 antigen, alpha polypeptide (p32) antibody;CD8a antibody;CD8a antigen antibody;CD8a molecule antibody;CD8A_HUMAN antibody;Leu2 antibody;Leu2 T lymphocyte antigen antibody;MAL antibody;OKT8 T cell antigen antibody;p32 antibody;T cell antigen Leu2 antibody;T cell co receptor antibody;T-cell surface glycoprotein CD8 alpha chain antibody;T-lymphocyte differentiation antigen T8/Leu-2 antibody;T8 T cell antigen antibody

SUBCELLULAR LOCATION

Cell membrane, Membrane, Secreted.

FUNCTION

Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses. In T-cells, functions primarily as a coreceptor for MHC class I molecule:peptide complex. The antigens presented by class I peptides are derived from cytosolic proteins while class II derived from extracellular proteins. Interacts simultaneously with the T-cell receptor (TCR) and the MHC class I proteins presented by antigen presenting cells (APCs). In turn, recruits the Src kinase LCK to the vicinity of the TCR-CD3 complex. LCK then initiates different intracellular signaling pathways by phosphorylating various substrates ultimately leading to lymphokine production, motility, adhesion and activation of cytotoxic T-lymphocytes (CTLs). This mechanism enables CTLs to recognize and eliminate infected cells and tumor cells. In NK-cells, the presence of CD8A homodimers at the cell surface provides a survival mechanism allowing conjugation and lysis of multiple target cells. CD8A homodimer molecules also promote the survival and differentiation of activated lymphocytes into memory CD8 T-cells.