CD80/B7-1 Rabbit Polyclonal Antibody (1007-8)

UNIPROT #

P33681

PROTEIN NAME

CD80/B7-1

SYNONYMS

Activation B7-1 antigen antibody;B lymphocyte activation antigen B7 antibody;B7 antibody;B7-1 antibody;B7-1 antigen antibody;B7.1 antibody;BB1 antibody;CD28 antigen ligand 1 antibody;CD28LG antibody;CD28LG1 antibody;CD80 antibody;CD80 antigen (CD28 antigen ligand 1, B7-1 antigen) antibody;CD80 antigen antibody;CD80 molecule antibody;CD80_HUMAN antibody;Costimulatory factor CD80 antibody;costimulatory molecule variant IgV-CD80 antibody;CTLA-4 counter-receptor B7.1 antibody;LAB7 antibody;T-lymphocyte activation antigen CD80 antibody

TISSUE SPECIFICITY

Expressed on activated B-cells, macrophages and dendritic cells.

SUBCELLULAR LOCATION

Membrane.

FUNCTION

CD80/B7-1 is a molecule found on activated B cells and monocytes which provides a costimulatory signal necessary for T cell activation and survival. After engagement of T-cell receptor with antigen in association with major histocompatibility complex class II, a second signal mediated through the binding of B7 to CD28 greatly upregulates the production of multiple lymphokines. B7-1 is a costimulatory molecule for the activation of both CD4+ and CD8+ T lymphocytes that prevents the induction of clonal anergy. Thus, the transfer of B7-1 genes into tumor cells can induce protective immunity and lead to tumor rejection of some tumors in model systems of in vivo tumor growth.