CD86 Recombinant Rabbit Monoclonal Antibody [SJ20-00] (ET1606-50)

UNIPROT #

P42081

PROTEIN NAME

CD86

SYNONYMS

Activation B7-2 antigen 3 antibody;Activation B7-2 antigen antibody;B-lymphocyte activation antigen B7-2 2 antibody;B-lymphocyte activation antigen B7-2 antibody;B7 2 antibody;B7 antibody;B7-2 antibody;B7.2 antibody;B70 antibody;B72 antigen antibody;BU63 antibody;CD28 antigen ligand 2 2 antibody;CD28 antigen ligand 2 antibody;Cd28l2 antibody;CD28LG2 antibody;CD86 antibody;CD86 antigen (CD28 antigen ligand 2, B7-2 antigen) 1, 2 antibody;CD86 antigen (CD28 antigen ligand 2, B7-2 antigen) antibody;CD86 antigen antibody;CD86 molecule antibody;CD86_HUMAN antibody;CLS1 antibody;CTLA-4 counter-receptor B7.2 2, 3 antibody;CTLA-4 counter-receptor B7.2 antibody;Early T-cell costimulatory molecule 1 antibody;ETC-1 antibody;FUN 1 antibody;FUN-1 antibody;LAB72 antibody;Ly-58 antibody;Ly58 antibody;MB7 antibody;MB7-2 antibody;Membrane glycoprotein antibody;MGC34413 antibody;T-lymphocyte activation antigen CD86 antibody;TS/A-2 antibody

TISSUE SPECIFICITY

Expressed by activated B-lymphocytes and monocytes.

POST-TRANSLATIONAL MODIFICATION

Polyubiquitinated; which is promoted by MARCH8 and results in endocytosis and lysosomal degradation.

SUBCELLULAR LOCATION

Cell membrane.

FUNCTION

Cluster of Differentiation 86 (also known as CD86 and B7-2) is a protein constitutively expressed on dendritic cells, Langerhans cells, macrophages, B-cells (including memory B-cells), and on other antigen-presenting cells. Along with CD80, CD86 provides costimulatory signals necessary for T cell activation and survival. Depending on the ligand bound, CD86 can signal for self-regulation and cell-cell association, or for attenuation of regulation and cell-cell disassociation. The CD86 gene encodes a type I membrane protein that is a member of the immunoglobulin superfamily. Alternative splicing results in two transcript variants encoding different isoforms. Additional transcript variants have been described, but their full-length sequences have not been determined. Roles of both CD80 and CD86 are studied in context of many pathologies. Selective inhibition of costimulatory inhibitors was examined in a model of allergic pulmonary inflammation and airway hyper-responsiveness (AHR). Since initial host response to Staphylococcus aureus, especially the immune response based on T cells, is a contributing factor in the pathogenesis of acute pneumonia, role of the CD80/CD86 pathway in pathogenesis was investigated. The costimulatory molecules were also investigated in context of Bronchial Astma, Treg in cancer, and immunotherapy.